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Unilateral cerebellar stroke disrupts movement preparation and motor imagery
- Publication Year :
- 2006
- Publisher :
- Elsevier, 2006.
-
Abstract
- Objective To assess motor cortex excitability, motor preparation and imagery in patients with unilateral cerebellar stroke with damage of the dentate nucleus by using transcranial magnetic stimulation (TMS). Method Eight patients with unilateral cerebellar lesions due to tromboembolic stroke and 10 age matched healthy subjects were enrolled. Resting (RMT) and active (AMT) motor threshold, cortical and peripheral silent period, evaluation of motor imagery, reaction time and premovement facilitation of motor evoked potential (MEP) were tested bilaterally using TMS. Results The RMT and AMT were found to be increased contra lateral to the affected cerebellar hemisphere while the cortical silent period was prolonged. In addition the amount of MEP facilitation during motor imagery and the pre-movement facilitation were reduced in the motor cortex contra lateral to the affected cerebellar hemisphere. The reaction time, performed with the symptomatic hand, was slower. Conclusions On the whole, our data confirm a role for the cerebellum in maintaining the excitability of primary motor area. Furthermore, patients with unilateral cerebellar stroke exhibit lateralized deficit of motor preparation and motor imagery. Significance Our results add to evidence that cerebellum contributes to specific aspects of motor preparation and motor imagery.
- Subjects :
- Male
Cerebellum
medicine.medical_specialty
medicine.medical_treatment
Movement
Cerebellar stroke
Resting Phase, Cell Cycle
Functional Laterality
Premovement facilitation
Physical medicine and rehabilitation
Motor imagery
Physiology (medical)
Cerebellar hemisphere
medicine
Humans
Evoked potential
Aged
Reaction time
Analysis of Variance
Motor Cortex
Middle Aged
Evoked Potentials, Motor
Sensory Systems
Transcranial magnetic stimulation
Stroke
Dentate nucleus
medicine.anatomical_structure
Neurology
Transcranial magnetic stimulation, TMS, Cerebellar stroke, Motor imagery, Reaction time, Premovement facilitation
Case-Control Studies
TMS
Imagination
Silent period
Female
Perception
Neurology (clinical)
Psychology
Neuroscience
Motor cortex
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bbb3a83195e737af6443a3e769e87406