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Dose-dependent arterial destiffening and inward remodeling after olmesartan in hypertensives with metabolic syndrome
- Source :
- Hypertension, 64(4), 709-+. LIPPINCOTT WILLIAMS & WILKINS
- Publication Year :
- 2014
-
Abstract
- Whether angiotensin receptor blockers can dose-dependently remodel the arterial wall during long-term treatment has been largely debated. In this phase III, multicenter, randomized, double-blind, parallel-group study, 133 subjects with hypertension and metabolic syndrome were assigned to olmesartan, either 20 mg (n=44), 40 mg (n=42), or 80 mg (n=47) once a day, according to a force titration design during a 1-year period. Office blood pressure, 24-hour blood pressure, aortic stiffness (carotid-femoral pulse wave velocity), and carotid parameters were measured at baseline, 24 weeks, and 52 weeks. Pulse wave velocity significantly decreased ( P P =0.0685) for a smaller effect of 20 mg, compared with 40 and 80 mg at week 52. When the 40 and 80 mg doses were combined (40/80 mg versus 20 mg), a significant blood pressure–independent reduction in pulse wave velocity (−0.61 m/s) was observed at week 52 ( P =0.0066), whereas the nonadjusted reduction was −1.31 m/s ( P
- Subjects :
- medicine.medical_specialty
hypertension
Carotid arteries
compliance
arteries
Internal medicine
medicine.artery
Internal Medicine
medicine
Pulse wave velocity
Aorta
business.industry
blood pressure
arterie
antihypertensive agents
medicine.disease
Compliance (physiology)
aorta
Blood pressure
Endocrinology
randomized controlled trial
Cardiology
antihypertensive agent
Aortic stiffness
Metabolic syndrome
business
Olmesartan
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 0194911X
- Database :
- OpenAIRE
- Journal :
- Hypertension, 64(4), 709-+. LIPPINCOTT WILLIAMS & WILKINS
- Accession number :
- edsair.doi.dedup.....bbbdc3fb8386fbbbdb5b64ad2751ec94