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Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients
- Source :
- Cancer Biology & Medicine, Cancer Biology & Medicine, Vol 13, Iss 4, Pp 459-468 (2016)
- Publication Year :
- 2016
- Publisher :
- China Anti-cancer Association, 2016.
-
Abstract
- Objective: The expression of B-cell lymphoma 2 (Bcl-2) seems to be influenced by the endocrine environment. Numerous reports demonstrate the diverse expression of Bcl-2 family members under sex steroid regulation. With the exception of estrogen-related tumors, androgen-related tumors have shown their characteristics in Bcl-2 expression. In this study, the status of Bcl-2 expression in male hepatocellular carcinoma (HCC) patients was examined to verify the high incidence of HCC in males.Methods: Tumor tissue microarray was used to examine Bcl-2 expression levels in 374 HCC cases including 306 males and 68 females. Kaplan-Meier method, log-rank test, and Cox proportional hazards model were applied to investigate the predictive value of Bcl-2 in HCC patients.Results: Immunohistochemistry analysis showed that male patients with higher Bcl-2 levels had significantly longer median survival time and recurrence time than those with lower levels. However, no significant differences in outcomes were found between different Bcl-2 levels in female patients. When the male patients were stratified into several age points, the level of Bcl-2 expression showed poorer predictive efficiency in the 45–49 and 55–60 age groups in andropause-age patients compared with other age groups. Bcl-2 was an independent prognostic factor for both overall survival (P < 0.0001) and recurrence time (P = 0.0001) in male patients. After excluding male patients in the 45–60 age group, the predictive efficiency was enhanced (n = 147, OS, P = 0.0002, TTR, P < 0.0001).Conclusions: Bcl-2 expression is an independent predictor of survival and recurrence in male HCC. Bcl-2 levels may also be regulated by androgens or androgen receptors in male HCC patients. Bcl-2 levels change and exhibit poor predictive efficiency when androgen levels vary dramatically (andropause age).
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Microarray
Hepatocellular carcinoma
medicine.drug_class
androgen
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Bcl-2
andropause
business.industry
Proportional hazards model
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Androgen
Lymphoma
Androgen receptor
030104 developmental biology
Endocrinology
Sex steroid
030220 oncology & carcinogenesis
Immunohistochemistry
Original Article
prognosis
business
Subjects
Details
- ISSN :
- 20953941
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancer Biology & Medicine
- Accession number :
- edsair.doi.dedup.....bbe991d3f0449251e64144dd33dfccae