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Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens
- Source :
- PLoS ONE, Vol 12, Iss 2, p e0172156 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- The strategies for developing rotavirus (RV) vaccines have always been controversial. At present, both the monovalent RV vaccine and the multivalent RV vaccine have displayed excellent safety and efficacy against RV infection and shown cross-reactive immunity, which laid the question whether the multivalent RV vaccine could be replaced by the monovalent RV vaccine. In this study, we focused on comparing the immunogenicity (serum neutralization activity and protection against homotypic and heterotypic RVs’ challenge) of individual standard RV strains (monovalent RV immunogens) and different combinations of them (multivalent RV immunogens). In result, RV immunogens showed general immunogenicity and heterotypic reaction but the multivalent RV immunogens exhibited greater serum neutralization activity and stronger heterotypic reaction than the monovalent RV immunogens (P
- Subjects :
- Rotavirus
0301 basic medicine
Viral Diseases
Physiology
lcsh:Medicine
Molting
Antibodies, Viral
medicine.disease_cause
Biochemistry
Neutralization
Mice
Fluorescence Microscopy
0302 clinical medicine
Immune Physiology
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
Enzyme-Linked Immunoassays
lcsh:Science
Antigens, Viral
Vaccines
Microscopy
Mice, Inbred ICR
Immune System Proteins
Multidisciplinary
biology
Immunogenicity
Vaccination
Light Microscopy
Vaccination and Immunization
Infectious Diseases
Female
Antibody
Research Article
Immunology
chemical and pharmacologic phenomena
Research and Analysis Methods
complex mixtures
Antibodies
Rotavirus Infections
03 medical and health sciences
Antigen
Immunity
Neutralization test
Vaccine Development
medicine
Animals
Antigens
Immunoassays
Rotavirus Infection
lcsh:R
Rotavirus Vaccines
Biology and Life Sciences
Proteins
Antibodies, Neutralizing
Virology
030104 developmental biology
Immunologic Techniques
biology.protein
lcsh:Q
Preventive Medicine
Physiological Processes
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....bbf3e05e4568437b45b17c4692d05c8a