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Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China
- Source :
- Journal of medical virology. 90(9)
- Publication Year :
- 2017
-
Abstract
- Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 2013 to December 2014; 51 (11.86%) and 6 (6.45%) specimens were HPeV positive, respectively. HPeV1A occurred in 28 (6.51%) and 6 (6.45%) individuals with diarrhea and controls, respectively, whereas HPeV1B (3.95%), HPeV3 (0.23%), HPeV4 (0.70%), and HPeV14 (a rare genotype, 0.47%) were only detected in individuals with diarrhea. There was no significant difference in the rate of HPeV detection between the 2 groups; however, the mean age of HPeV infection was significantly lower in males. We conclude that HPeVs may be opportunistic pathogens associated with acute diarrhea. Immunocompromised individuals, such as children aged under 2 years and the elderly, could be vulnerable to HPeV infections.
- Subjects :
- 0301 basic medicine
Adult
Diarrhea
Male
medicine.medical_specialty
Acute diarrhea
China
Adolescent
Genotype
Parechovirus
Opportunistic Infections
Gastroenterology
03 medical and health sciences
Feces
Young Adult
Sex Factors
Virology
Internal medicine
medicine
Prevalence
Humans
Child
Phylogeny
Aged
Aged, 80 and over
Molecular Epidemiology
Picornaviridae Infections
biology
Phylogenetic tree
business.industry
Human parechovirus
Significant difference
Infant, Newborn
Genetic Variation
Infant
Mean age
Middle Aged
biology.organism_classification
030104 developmental biology
Infectious Diseases
Child, Preschool
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 10969071
- Volume :
- 90
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of medical virology
- Accession number :
- edsair.doi.dedup.....bbf99cad41e5fd26e170f5458d185263