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Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models
- Source :
- International Journal of Obesity, International Journal of Obesity, Nature Publishing Group, 2012, 36 (4), pp.581-94. ⟨10.1038/ijo.2011.113⟩, International Journal of Obesity, 2012, 36 (4), pp.581-94. ⟨10.1038/ijo.2011.113⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- International audience; Adipose tissue lipolysis is the catabolic process whereby stored triacylglycerol (TAG) is broken down by lipases into fatty acids and glycerol. Here, we review recent insights from transgenic mouse models. Genetic manipulations affecting lipases are considered first, followed by transgenic models of lipase co-factors and lastly non-lipase lipid droplet (LD)-associated proteins. The central role of hormone-sensitive lipase (HSL), long considered to be the sole rate-limiting enzyme of TAG hydrolysis, has been revised since the discovery of adipose triglyceride lipase (ATGL). It is now accepted that ATGL initiates TAG breakdown producing diacylglycerol, which is subsequently hydrolyzed by HSL. Furthermore, lipase activities are modulated by co-factors whose deletion causes severe metabolic disturbances. Another major advance has come from the description of the involvement of non-lipase proteins in the regulation of lipolysis. The role of perilipins has been extensively investigated. Other newly discovered LD-associated proteins have also been shown to regulate lipolysis.
- Subjects :
- MESH: Triglycerides
MESH: Mice, Transgenic
Lipolysis
Endocrinology, Diabetes and Metabolism
Perilipin 2
Medicine (miscellaneous)
Adipose tissue
Mice, Transgenic
030209 endocrinology & metabolism
MESH: Carrier Proteins
[SDV.GEN] Life Sciences [q-bio]/Genetics
Fatty Acid-Binding Proteins
MESH: Fatty Acid-Binding Proteins
Perilipin-2
Perilipin-3
Mice
03 medical and health sciences
0302 clinical medicine
Lipid droplet
Adipocytes
Contactin 2
Animals
MESH: Animals
MESH: Lipolysis
Lipase
MESH: Mice
Triglycerides
MESH: Adipocytes
030304 developmental biology
Diacylglycerol kinase
0303 health sciences
[SDV.GEN]Life Sciences [q-bio]/Genetics
Nutrition and Dietetics
MESH: Sterol Esterase
biology
Chemistry
Membrane Proteins
Sterol Esterase
Biochemistry
Adipose triglyceride lipase
biology.protein
Perilipin
MESH: Contactin 2
MESH: Membrane Proteins
Carrier Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 03070565
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity, International Journal of Obesity, Nature Publishing Group, 2012, 36 (4), pp.581-94. ⟨10.1038/ijo.2011.113⟩, International Journal of Obesity, 2012, 36 (4), pp.581-94. ⟨10.1038/ijo.2011.113⟩
- Accession number :
- edsair.doi.dedup.....bbfd3a5b0dab3d72a58af835e89639ac