Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate

Authors :: Weirong Lai
Shengyan Zhao
Qinhuai Lai
Wei Zhou
Mengdan Wu
Xiaohua Jiang
Xin Wang
Yujia Peng
Xian Wei
Liang Ouyang
Lantu Gou
Hao Chen
Yuxi Wang
Jinliang Yang
Source :: Journal of medicinal chemistry. 65(17)
Publication Year :: 2022
Abstract: A novel series of hybrid molecules combining pyrrolobenzodiazepine (PBD) and anthracenecarboxyimide pharmacophores were designed, synthesized, and tested for

Subjects :: Benzodiazepines
Mice
Immunoconjugates
Receptor, ErbB-2
Cell Line, Tumor
Drug Discovery
Molecular Medicine
Animals
Humans
Pyrroles
Trastuzumab
Xenograft Model Antitumor Assays

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