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Effect of continuous positive airway pressure on carotid intima-media thickness in patients with obstructive sleep apnea: A meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 9, p e0184293 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science, 2017.
-
Abstract
- Objective Obstructive sleep apnea (OSA) is associated with increased carotid intima-media thickness (IMT), an early marker of atherosclerosis. Continuous positive airway pressure (CPAP) is the first-line treatment for OSA. A meta-analysis was performed to determine whether CPAP therapy could decrease carotid IMT. Methods The PubMed, Embase, Web of Science, and Cochrane library were searched before March, 2017. Weighted mean difference (WMD) was calculated to estimate the treatment effects of pre and post-CPAP therapy. Seven studies were examined and the meta-analysis was performed using STATA 12.0. Results There was no change of carotid IMT before and after CPAP treatment in OSA patients (WMD = 0.052, 95% confidence interval (CI) = -0.002 to 0.105, z = 1.90, p = 0.057). Meanwhile, meta-analysis of the two RCTs showed that carotid IMT was not changed in CPAP group when compared with control group (WMD = 0.002 95% CI = -0.125 to 0.129, z = 0.03, p = 0.976). Subgroup analyses indicated that carotid IMT was significantly decreased after CPAP use in more severe OSA patients (AHI≥50) (WMD = 0.073, 95% CI = 0.022 to 0.124, z = 2.80, p = 0.005) and patients with therapeutic duration ≥6 months (WMD = 0.121, 95% CI = 0.019 to 0.223, z = 2.32, p = 0.021). Conclusions CPAP had no impact on carotid IMT in OSA patients. However, carotid IMT was significantly decreased after CPAP treatment in more severe OSA patients and patients with longer CPAP usage.
- Subjects :
- Male
Pulmonology
Apnea
medicine.medical_treatment
lcsh:Medicine
Cochrane Library
Pathology and Laboratory Medicine
Vascular Medicine
Carotid Intima-Media Thickness
0302 clinical medicine
Mathematical and Statistical Techniques
Medicine and Health Sciences
Continuous positive airway pressure
lcsh:Science
Cognitive Impairment
Stenosis
Clinical Trials as Topic
Sleep Apnea, Obstructive
Multidisciplinary
Continuous Positive Airway Pressure
Cognitive Neurology
Sleep apnea
Middle Aged
Carotid Arteries
Neurology
Research Design
Meta-analysis
Physical Sciences
Cardiology
cardiovascular system
Observational Studies
Female
Statistics (Mathematics)
Algorithms
Research Article
Adult
medicine.medical_specialty
Drug Research and Development
Sleep Apnea
Cognitive Neuroscience
Research and Analysis Methods
Sensitivity and Specificity
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Humans
In patient
Clinical Trials
cardiovascular diseases
Statistical Methods
Pharmacology
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Atherosclerosis
Confidence interval
Randomized Controlled Trials
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
030228 respiratory system
Intima-media thickness
Cognitive Science
lcsh:Q
Clinical Medicine
business
Sleep Disorders
030217 neurology & neurosurgery
Mathematics
Meta-Analysis
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....bc0a361ac819c6535c31f1b93771f704