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Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention
- Source :
- Journal of Cardiology. 77:41-47
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Heart failure (HF) is a risk factor for adverse post-procedural outcome after revascularization; however, it is unclear how left ventricular systolic dysfunction (LVSD) and clinical HF symptoms affect percutaneous coronary intervention (PCI) outcomes. We investigated the characteristics and long-term outcomes of patients with clinical HF or LVSD after PCI.This was a Japanese multicenter registry study of adult patients receiving PCI. Among 4689 consecutive patients who underwent PCI at 15 hospitals from January 2009 to December 2012, we analyzed 2634 (56.2%) with documented left ventricular ejection fraction (LVEF). They were divided into four groups based on clinical HF (symptoms or HF hospitalization) and LVEF [≥35% and35% (HF due to LVSD)]. The primary outcome was major adverse cardiovascular events (MACE), comprising all-cause death, acute coronary syndrome, HF hospitalization, performance of coronary artery bypass grafting, and stroke within 2 years after the initial PCI.Our findings revealed 354 patients (13.4%) with HF (clinical HF, n = 173, 48.9%; LVSD, n = 132, 37.3%; both, n = 49; 13.8%). The incidence of MACE was higher in patients with clinical HF or LVSD, and was largely due to higher non-cardiac death and HF hospitalization. After adjustment, clinical HF (hazard ratio 2.16, 95% confidence interval; 1.49-3.14) and lower LVEF (per 10%, hazard ratio 0.89, 95% confidence interval; 0.81-0.99) were independently associated with higher MACE risk.Clinical HF and LVSD were independently associated with adverse long-term clinical outcomes, particularly with non-cardiac death and HF readmission, in patients treated with PCI.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
Ventricular Function, Left
Ventricular Dysfunction, Left
03 medical and health sciences
Percutaneous Coronary Intervention
Postoperative Complications
0302 clinical medicine
Japan
Cause of Death
Internal medicine
medicine
Humans
Registries
cardiovascular diseases
030212 general & internal medicine
Risk factor
Aged
Proportional Hazards Models
Heart Failure
Ejection fraction
business.industry
Incidence
Hazard ratio
Percutaneous coronary intervention
Stroke Volume
Middle Aged
medicine.disease
Confidence interval
Hospitalization
Stroke
Treatment Outcome
Heart Disease Risk Factors
Heart failure
Conventional PCI
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Mace
Subjects
Details
- ISSN :
- 09145087
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....bc1eab2c014048f7722c410818149bc1