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Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More
- Source :
- Biologicalpharmaceutical bulletin. 43(3)
- Publication Year :
- 2020
-
Abstract
- Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.
- Subjects :
- 0301 basic medicine
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Pharmaceutical Science
chemistry.chemical_element
behavioral disciplines and activities
03 medical and health sciences
chemistry.chemical_compound
Plasma
Selenium
0302 clinical medicine
Internal medicine
Selenoprotein P
medicine
Animals
Humans
Pharmacology
Pulmonary Arterial Hypertension
Selenocysteine
business.industry
musculoskeletal, neural, and ocular physiology
Type 2 Diabetes Mellitus
General Medicine
Prognosis
body regions
030104 developmental biology
Endocrinology
chemistry
Diabetes Mellitus, Type 2
030220 oncology & carcinogenesis
population characteristics
business
Biomarkers
Subjects
Details
- ISSN :
- 13475215
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biologicalpharmaceutical bulletin
- Accession number :
- edsair.doi.dedup.....bc20a5dc7624964348fe0827a37ce483