Back to Search
Start Over
RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data
- Source :
- Nucleic Acids Research, Research Repository of Catalonia, UPF Digital Repository, Archivio della ricerca-Università di Roma La Sapienza, PubMed Central, Recercat. Dipósit de la Recerca de Catalunya, instname
- Publication Year :
- 2018
- Publisher :
- Oxford University Press, 2018.
-
Abstract
- Protein-RNA interactions are implicated in a number of physiological roles as well as diseases, with molecular mechanisms ranging from defects in RNA splicing, localization and translation to the formation of aggregates. Currently, ∼1400 human proteins have experimental evidence of RNA-binding activity. However, only ∼250 of these proteins currently have experimental data on their target RNAs from various sequencing-based methods such as eCLIP. To bridge this gap, we used an established, computationally expensive protein-RNA interaction prediction method, catRAPID, to populate a large database, RNAct. RNAct allows easy lookup of known and predicted interactions and enables global views of the human, mouse and yeast protein-RNA interactomes, expanding them in a genome-wide manner far beyond experimental data (http://rnact.crg.eu). European Research Council [RIBOMYLOME_309545]; European Union's Horizon 2020 research and innovation programme [727658, IASIS]; Spanish Ministry of Economy and Competitiveness [BFU2014-55054-P, BFU2017-86970-P]; Spanish Ministry of Economy and Competitiveness; ‘Centro de Excelencia Severo Ochoa 2013-2017’; CERCA Programme of the Generalitat de Catalunya; Marie Sklodowska-Curie Individual Fellowship from the European Union's Horizon 2020 research and innovation programme (793135, ‘DeepRNA’ to B.L.). Funding for open access charge: European Research Council [RIBOMYLOME_309545], European Union [793135].
- Subjects :
- ved/biology.organism_classification_rank.species
Computational biology
Biology
03 medical and health sciences
Mice
0302 clinical medicine
Yeasts
Databases, Genetic
Protein Interaction Mapping
Genetics
Animals
Humans
Database Issue
Protein Interaction Maps
Model organism
Human proteins
030304 developmental biology
0303 health sciences
ved/biology
Experimental data
RNA
RNA-Binding Proteins
Translation (biology)
Genomics
RNA splicing
030217 neurology & neurosurgery
Software
Protein Binding
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research, Research Repository of Catalonia, UPF Digital Repository, Archivio della ricerca-Università di Roma La Sapienza, PubMed Central, Recercat. Dipósit de la Recerca de Catalunya, instname
- Accession number :
- edsair.doi.dedup.....bc32e922d00eea0d7894c21c20321450