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Prognostic value of the absolute lymphocyte count in patients admitted for acute heart failure

Authors :
Marco Metra
Ivano Bonadei
Elio Gorga
Anna Isotta Castrini
Carlo Lombardi
Alice Ravera
Valentina Carubelli
Source :
Journal of Cardiovascular Medicine. 18:859-865
Publication Year :
2017
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2017.

Abstract

Low relative lymphocyte count is an important prognostic marker in acute heart failure (AHF); however, it could be influenced by other abnormalities in white cells count. Our purpose is to evaluate if low absolute lymphocyte count (ALC) is an independent predictor of events in patients with AHF. In a retrospective analysis, we included 309 patients with AHF, divided into two groups according to the median value of ALC at admission (1410 cells/μl). The primary end point was all-cause mortality or urgent heart transplantation within 1 year. Patients with low ALC were older and had more comorbidity, namely atrial fibrillation, chronic kidney disease, chronic obstructive pulmonary disease and anemia. Low ALC was associated with higher all-cause mortality or urgent heart transplantation at 1 year (24.3 vs 13.0%; P = 0.012). In a multivariable model, the independent predictors of mortality at 1 year were ALC 1410 cells/μl or less at admission [hazard ratio 2.04; CI (confidence interval) 95% (1.06–3.95); P = 0.033], age [hazard ratio 1.08; CI 95% (1.04–1.12); P

Details

ISSN :
15582027
Volume :
18
Database :
OpenAIRE
Journal :
Journal of Cardiovascular Medicine
Accession number :
edsair.doi.dedup.....bc3b3cf12e893450d00b1d8a19e065a7