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Pathologic Assessment of Rectal Carcinoma after Neoadjuvant Radio(chemo)therapy: Prognostic Implications

Authors :
Liesbeth Ferdinande
Piet Pattyn
Monirath Hav
Claude Cuvelier
Louis Libbrecht
Karen Geboes
UCL - SSS/IREC/SLUC - Pôle St.-Luc
UCL - (SLuc) Service d'anatomie pathologique
Source :
BioMed Research International, Vol. 2015, p. 574540 [1-11] (2015), BioMed Research International, BIOMED RESEARCH INTERNATIONAL, BioMed Research International, Vol 2015 (2015)
Publication Year :
2015
Publisher :
Hindawi Limited, 2015.

Abstract

Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. Surgical pathologists play an important role in determining the many facets of rectal carcinoma patient care after neoadjuvant treatment. These range from proper handling of macroscopic specimens to accurate microscopic evaluation of pathological features associated with patients’ prognosis. This review presents the well-established pathological prognostic indicators and discusses challenging features in order to provide both surgical pathologists and treating physicians with a checklist that is useful in a neoadjuvant setting.

Details

ISSN :
23146141 and 23146133
Volume :
2015
Database :
OpenAIRE
Journal :
BioMed Research International
Accession number :
edsair.doi.dedup.....bc3dc976b06ec5ff5c66464d838edf16
Full Text :
https://doi.org/10.1155/2015/574540