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Pathologic Assessment of Rectal Carcinoma after Neoadjuvant Radio(chemo)therapy: Prognostic Implications
- Source :
- BioMed Research International, Vol. 2015, p. 574540 [1-11] (2015), BioMed Research International, BIOMED RESEARCH INTERNATIONAL, BioMed Research International, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. Surgical pathologists play an important role in determining the many facets of rectal carcinoma patient care after neoadjuvant treatment. These range from proper handling of macroscopic specimens to accurate microscopic evaluation of pathological features associated with patients’ prognosis. This review presents the well-established pathological prognostic indicators and discusses challenging features in order to provide both surgical pathologists and treating physicians with a checklist that is useful in a neoadjuvant setting.
- Subjects :
- medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
lcsh:Medicine
Review Article
General Biochemistry, Genetics and Molecular Biology
Rectal carcinoma
Medicine and Health Sciences
medicine
Humans
Pathological
Neoadjuvant therapy
Neoplasm Staging
Preoperative treatment
Inflammation
General Immunology and Microbiology
Rectal Neoplasms
business.industry
lcsh:R
Mucins
Cell Differentiation
Chemoradiotherapy
General Medicine
Prognosis
medicine.disease
Neoadjuvant Therapy
Surgery
Treatment Outcome
Chemo therapy
Curative surgery
Lymph Nodes
Radiology
business
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....bc3dc976b06ec5ff5c66464d838edf16
- Full Text :
- https://doi.org/10.1155/2015/574540