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Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018
- Source :
- Eurosurveillance, Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (37), ⟨10.2807/1560-7917.ES.2021.26.37.2001213⟩, Eurosurveillance, 2021, 26 (37), ⟨10.2807/1560-7917.ES.2021.26.37.2001213⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Background Bordetella pertussis is the main agent of whooping cough. Vaccination with acellular pertussis vaccines has been largely implemented in high-income countries. These vaccines contain 1 to 5 antigens: pertussis toxin (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and/or fimbrial proteins (FIM2 and FIM3). Monitoring the emergence of B. pertussis isolates that might partially escape vaccine-induced immunity is an essential component of public health strategies to control whooping cough. Aim We aimed to investigate temporal trends of fimbriae serotypes and vaccine antigen-expression in B. pertussis over a 23-year period in France (1996–2018). Methods Isolates (n = 2,280) were collected through hospital surveillance, capturing one third of hospitalised paediatric pertussis cases. We assayed PT, FHA and PRN production by Western blot (n = 1,428) and fimbriae production by serotyping (n = 1,058). Molecular events underlying antigen deficiency were investigated by genomic sequencing. Results The proportion of PRN-deficient B. pertussis isolates has increased steadily from 0% (0/38) in 2003 to 48.4% (31/64) in 2018 (chi-squared test for trend, p 481 insertion within the prn gene or a 22 kb genomic inversion involving the prn promoter sequence, indicative of convergent evolution. FIM2-expressing isolates have emerged since 2011 at the expense of FIM3. Conclusions B. pertussis is evolving through the rapid increase of PRN-deficient isolates and a recent shift from FIM3 to FIM2 expression. Excluding PRN, the loss of vaccine antigen expression by circulating B. pertussis isolates is epidemiologically insignificant.
- Subjects :
- Serotype
Bordetella pertussis
population evolution
Whooping Cough
Epidemiology
[SDV]Life Sciences [q-bio]
Fimbria
MESH: Pertussis Toxin
MESH: Virulence Factors, Bordetella
Pertussis toxin
Microbiology
pertactin
MESH: Bordetella pertussis
03 medical and health sciences
0302 clinical medicine
Antigen
Virology
MESH: Child
medicine
Humans
Virulence Factors, Bordetella
030212 general & internal medicine
Child
Whooping cough
030304 developmental biology
Pertussis Vaccine
vaccine antigen deficiency
0303 health sciences
Surveillance
MESH: Humans
biology
MESH: Bacterial Outer Membrane Proteins
Public Health, Environmental and Occupational Health
MESH: Whooping Cough
biology.organism_classification
medicine.disease
fimbriae serotype
3. Good health
respiratory tract diseases
Vaccination
MESH: France
Pertussis Toxin
MESH: Pertussis Vaccine
France
Pertactin
Bacterial Outer Membrane Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 15607917 and 1025496X
- Database :
- OpenAIRE
- Journal :
- Eurosurveillance, Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (37), ⟨10.2807/1560-7917.ES.2021.26.37.2001213⟩, Eurosurveillance, 2021, 26 (37), ⟨10.2807/1560-7917.ES.2021.26.37.2001213⟩
- Accession number :
- edsair.doi.dedup.....bc500a268b7671b129ae98bc3c7ce5dd