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Molecular biomarkers in the context of focal therapy for prostate cancer: recommendations of a Delphi Consensus from the Focal Therapy Society

Authors :
Varaha S Tammisetti
Peter-Paul Willemse
Daniel Rukstalis
Veeru Kasivisvanathan
Xavier Cathelineau
Yoh Matsuoka
Willemien Van Den Bos
Giorgio Gandaglia
Soroush Rais-Bahrami
Takumi Shiraishi
Massimo Valerio
Ardeshir R. Rastinehad
Cary N. Robertson
Herbert Lepor
Rajan T Gupta
Juan Gomez Rivas
Toshitaka Shin
Ariel Schulman
Yann Barbe
A.L. Abreu
Marco Moschini
Arvin K. George
Marco Oderda
Armando Stabile
Amir H. Lebastchi
Nathan Lawrentschuk
Daniel Margolis
Georg Salomon
M.P. Laguna
Wei Phin Tan
Jean J.M.C.H. de la Rosette
Derek Lomas
Christian P Pavlovich
Hazem Orabi
Bernard Malavaud
Abhinav Sidana
Osamu Ukimura
Sherif Mehralivand
Justin Gregg
Fernando Bianco
Thomas J. Polascik
Jochen Walz
Giancarlo Marra
Petr Macek
Rafael Sanchez-Salas
Sunao Shoji
Mesut Remzi
A. Villers
Radiology and Nuclear Medicine
APH - Personalized Medicine
Marra, Giancarlo
Laguna, Maria Pilar
Walz, Jochen
Pavlovich, Christian P
Bianco, Fernando
Gregg, Justin
Lebastchi, Amir H
Lepor, Herbert
Macek, Petr
Rais-Bahrami, Soroush
Robertson, Cary
Rukstalis, Daniel
Salomon, Georg
Ukimura, Osamu
Abreu, Andre L
Barbe, Yann
Cathelineau, Xavier
Gandaglia, Giorgio
George, Arvin K
Rivas, Juan Gomez
T Gupta, Rajan
Lawrentschuk, Nathan
Kasivisvanathan, Veeru
Lomas, Derek
Malavaud, Bernard
Margolis, Daniel
Matsuoka, Yoh
Mehralivand, Sherif
Moschini, Marco
Oderda, Marco
Orabi, Hazem
Rastinehad, Ardeshir R
Remzi, Mesut
Schulman, Ariel
Shin, Toshitaka
Shiraishi, Takumi
Sidana, Abhinav
Shoji, Sunao
Stabile, Armando
Valerio, Massimo
Tammisetti, Varaha S
Tan, Wei Phin
Van Den Bos, Willemien
Villers, Arnaud
Willemse, Peter-Paul
de la Rosette, Jean
Polascik, Thoma
Sanchez-Salas, Rafael
Urology
Source :
Minerva Urology and Nephrology, 74(5), 581-589. Edizioni Minerva Medica S.p.A., Minerva Urology and Nephrology, 74(5), 581-589. Edizioni Minerva Medica
Publication Year :
2022

Abstract

Background Focal Therapy (FT) for Prostate Cancer (PCa) is promising. However, long-term oncological results are awaited and there is no consensus on follow-up strategies. Molecular biomarkers (MB) may be useful in selecting, treating and following up men undergoing FT, though there is limited evidence in this field to guide practice. We aimed to conduct a consensus meeting, endorsed by the Focal Therapy Society, amongst a large group of experts, to understand the potential utility of MB in FT for localised PCa. Materials and methods A 38-item questionnaire was built following a literature search. The authors then performed three rounds of a Delphi Consensus using DelphiManager, using the GRADE grid scoring system, followed by a face-to-face expert meeting. Three areas of interest were identified and covered concerning MB for FT, i) the current/present role; ii) the potential/future role; iii) the recommended features for future studies. Consensus was defined using a 70% agreement threshold. Results Of 95 invited experts, 42 (44.2%) completed the three Delphi rounds. Twenty-four items reached a consensus and they were then approved at the meeting involving (n=15) experts. Fourteen items reached a consensus on uncertainty, or they did not reach a consensus. They were re-discussed, resulting in a consensus (n=3), a consensus on a partial agreement (n=1), and a consensus on uncertainty (n=10). A final list of statements were derived from the approved and discussed items, with the addition of three generated statements, to provide guidance regarding MB in the context of FT for localised PCa. Research efforts in this field should be considered a priority. Conclusions The present study detailed an initial consensus on the use of MB in FT for PCa. This is until evidence becomes available on the subject.

Details

Language :
English
ISSN :
27246051
Database :
OpenAIRE
Journal :
Minerva Urology and Nephrology, 74(5), 581-589. Edizioni Minerva Medica S.p.A., Minerva Urology and Nephrology, 74(5), 581-589. Edizioni Minerva Medica
Accession number :
edsair.doi.dedup.....bc5674c39c2c1157340f1c0353262367