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Evaluation of different periods of estrogen replacement onset in the tibia of ovariectomized rats
- Source :
- Aging Clinical and Experimental Research. 26:465-471
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Estrogen deficiency results in increased bone turnover and can lead to osteoporosis. Hormone replacement therapy (HRT) seems to be the most effective means of reducing bone loss and fractures. However, the effects of the period of HRT onset on bone tissue require further elucidation. This study aimed to evaluate the effects of different periods of HRT onset on the trabecular bone of ovariectomized rats. Seventy-five ovariectomized Wistar rats were divided into five groups according to the onset of treatment. Each group was subdivided into experimental (E; n = 10) and control (C; n = 5), according to treatment with 17-β-estradiol or vehicle alone (soybean oil), respectively, administered subcutaneously. The first group received treatment immediately post-surgery, while treatment in the remaining groups was initiated 1, 2, 3 and 4 weeks post-surgery. Euthanasia occurred at 9 weeks post-surgery. The left tibias were removed and prepared for histomorphometric analyses. The histomorphometric results were statistically analyzed by the Student’s t test (p
- Subjects :
- Aging
medicine.medical_specialty
Time Factors
medicine.drug_class
Ovariectomy
medicine.medical_treatment
Osteoporosis
Bone tissue
Bone and Bones
Body Mass Index
Bone remodeling
Bone Density
Internal medicine
medicine
Animals
Estrogen replacement
Tibia
Rats, Wistar
Estradiol
business.industry
Estrogen Replacement Therapy
Hormone replacement therapy (menopause)
medicine.disease
Rats
Disease Models, Animal
Treatment Outcome
Endocrinology
medicine.anatomical_structure
Estrogen
Ovariectomized rat
Female
Geriatrics and Gerontology
business
Subjects
Details
- ISSN :
- 17208319
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Aging Clinical and Experimental Research
- Accession number :
- edsair.doi.dedup.....bc6a2ba15a7f0440b856abae153ffb48