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Identification of proprioceptive thalamocortical tracts in children: comparison of fMRI, MEG, and manual seeding of probabilistic tractography
- Source :
- Cerebral Cortex. 32:3736-3751
- Publication Year :
- 2022
- Publisher :
- Oxford University Press (OUP), 2022.
-
Abstract
- Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press. Studying white matter connections with tractography is a promising approach to understand the development of different brain processes, such as proprioception. An emerging method is to use functional brain imaging to select the cortical seed points for tractography, which is considered to improve the functional relevance and validity of the studied connections. However, it is unknown whether different functional seeding methods affect the spatial and microstructural properties of the given white matter connection. Here, we compared functional magnetic resonance imaging, magnetoencephalography, and manual seeding of thalamocortical proprioceptive tracts for finger and ankle joints separately. We showed that all three seeding approaches resulted in robust thalamocortical tracts, even though there were significant differences in localization of the respective proprioceptive seed areas in the sensorimotor cortex, and in the microstructural properties of the obtained tracts. Our study shows that the selected functional or manual seeding approach might cause systematic biases to the studied thalamocortical tracts. This result may indicate that the obtained tracts represent different portions and features of the somatosensory system. Our findings highlight the challenges of studying proprioception in the developing brain and illustrate the need for using multimodal imaging to obtain a comprehensive view of the studied brain process.
- Subjects :
- magnetoencephalography
SOMATOSENSORY CORTEX
Cognitive Neuroscience
SEGMENTATION
neurofysiologia
PASSIVE FINGER
3124 Neurology and psychiatry
CORTICOSPINAL TRACT
Cellular and Molecular Neuroscience
toiminnallinen magneettikuvaus
primary sensorimotor cortex
CONNECTIVITY
Humans
magnetic resonance imaging
Child
DIFFUSION TENSOR TRACTOGRAPHY
MOTOR CORTEX
Brain Mapping
MEG
transkraniaalinen magneettistimulaatio
magneettikuvaus
multimodal
3112 Neurosciences
diagnostiikka
Proprioception
FUNCTIONAL MRI
REGIONS
White Matter
CORTICAL ACTIVATION
kuvantaminen
aivokuori
passive movement
aivot
Subjects
Details
- ISSN :
- 14602199 and 10473211
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Cerebral Cortex
- Accession number :
- edsair.doi.dedup.....bc82965bf48c20e882b36d846f84fd80