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Maintaining Low HIV Type 1 Env Genetic Diversity among Injection Drug Users Infected with a B/C Recombinant and CRF01_AE HIV Type 1 in Southern China

Authors :
Jie Chen
Francine E. McCutchan
Xiao Fang Yu
Sucheep Piyasirisilp
Shenghan Lai
Wei Kong
Wei Liu
Fuxiong Liang
Qiuying Zhu
Bindong Liu
Source :
AIDS Research and Human Retroviruses. 18:167-170
Publication Year :
2002
Publisher :
Mary Ann Liebert Inc, 2002.

Abstract

HIV-1 outbreaks in Guangxi Province, southern China were initiated from two separate border cities in 1996 and 1997. Drug users in Pingxiang City, which borders Vietnam, were infected with CRF01_AE HIV-1, and drug users in Baise City, which borders Yunan Province, were infected with a novel B/C recombinant HIV-1. Since 1997, HIV-1 has been rapidly spreading in Guangxi, including its capital city Nanning. Survey data indicated that HIV-1 prevalence among IDUs in new outbreak regions increased 8 to 42% within 1 year. The B/C recombinants obtained from five separate regions in Guangxi, which span a 4-year time frame, were remarkable for their low intersubject env V3 diversity, less than 0.2%. Similarly, the CRF01_AE from IDUs over a 3-year time frame had low intersubject env V3 diversity of less than 1.6%. Different patterns of sequence variations in the V3 and V4 regions were observed for the B/C recombinant and the CRF01_AE HIV1. The rapid spreading of homogeneous HIV-1 strains in Guangxi may have important implications for HIV transmission as well as vaccine development and evaluation.

Details

ISSN :
19318405 and 08892229
Volume :
18
Database :
OpenAIRE
Journal :
AIDS Research and Human Retroviruses
Accession number :
edsair.doi.dedup.....bc8a420cdd8d297573bd91aa1edb70a6