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LncRNAs as novel indicators of patients' prognosis in stage i epithelial ovarian cancer: A retrospective and multicentric study
- Publication Year :
- 2017
- Publisher :
- American Association for Cancer Research Inc., 2017.
-
Abstract
- Purpose: Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs and is characterized by good prognosis with fewer than 20% of patients relapsing. As it occurs less frequently than advanced-stage EOC, its molecular features have not been thoroughly investigated. We have demonstrated that in stage I EOC miR-200c-3p can predict patients' outcome. In the present study, we analyzed the expression of long non-coding RNAs (lncRNA) to enable potential definition of a non-coding transcriptional signature with prognostic relevance for stage I EOC. Experimental Design: 202 snap-frozen stage I EOC tumor biopsies, 47 of which relapsed, were gathered together from three independent tumor tissue collections and subdivided into a training set (n = 73) and a validation set (n = 129). Median follow up was 9 years. LncRNAs' expression profiles were correlated in univariate and multivariate analysis with overall survival (OS) and progression-free survival (PFS). Results: The expression of lnc-SERTAD2-3, lnc-SOX4-1, lnc-HRCT1-1, and PVT1 was associated in univariate and multivariate analyses with relapse and poor outcome in both training and validation sets (P < 0.001). Using the expression profiles of PVT1, lnc-SERTAD2-3, and miR-200c-3p simultaneously, it was possible to stratify patients into high and low risk. The OS for high- and low-risk individuals are 36 and 123 months, respectively (OR, 15.55; 95% confidence interval, 3.81–63.36). Conclusions: We have identified a non-coding transcriptional signature predictor of survival and biomarker of relapse for stage I EOC. Clin Cancer Res; 23(9); 2356–66. ©2016 AACR.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
Multivariate analysis
Kaplan-Meier Estimate
Carcinoma, Ovarian Epithelial
Bioinformatics
0302 clinical medicine
lncRNA
Neoplasms
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Tumor
Glandular and Epithelial
Middle Aged
Prognosis
Gene Expression Regulation, Neoplastic
Adult
Aged
Biomarkers, Tumor
Disease-Free Survival
Female
Humans
Neoplasm Staging
RNA, Long Noncoding
Retrospective Studies
ovarian cancer
030220 oncology & carcinogenesis
Biomarker (medicine)
Long Noncoding
medicine.medical_specialty
03 medical and health sciences
Median follow-up
Internal medicine
medicine
Carcinoma
Neoplastic
business.industry
Cancer
Retrospective cohort study
medicine.disease
Confidence interval
030104 developmental biology
Gene Expression Regulation
RNA
business
Ovarian cancer
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bc979bcd52043f84735f096c03177297