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Impact of congenital heart disease on outcomes after primary repair of esophageal atresia: a retrospective observational study using a nationwide database in Japan
- Source :
- Pediatric Surgery International. 35:1077-1083
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- To verify the association between congenital heart disease (CHD) and postoperative complications after primary repair of esophageal atresia in patients from a Japanese nationwide database. We identified babies in the Diagnosis Procedure Combination database who underwent radical surgery for esophageal atresia from 2010 to 2016. We used multivariable logistic regression analyses to evaluate the occurrence of anastomotic leakage and anastomotic stricture. Among 431 patients who underwent primary anastomosis, 114 patients (27%) had CHD. Anastomotic leakage occurred in 77 patients (17.9%) and stricture in 154 (35.7%). Compared with patients whose anesthetic duration was less than 240 min, those with anesthesia lasting from 240 to 360 min (odds ratio 2.49; 95% confidence interval (CI) 1.17–5.27; p = 0.02) or more than 360 min (odds ratio 4.10; 95% CI 1.69–9.96; p = 0.002) were more likely to experience anastomotic leakage. Male patients had a lower risk of anastomotic stricture than female patients (odds ratio 0.65; 95% CI 0.43–0.9; p = 0.04). CHD was not associated with anastomotic leakage or stricture. The only significant predictor of anastomotic leakage was duration of anesthesia.
- Subjects :
- Heart Defects, Congenital
Male
medicine.medical_specialty
Heart disease
Anastomotic Leak
Anastomosis
Lower risk
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Japan
030225 pediatrics
Pediatric surgery
medicine
Humans
Abnormalities, Multiple
Radical surgery
Esophageal Atresia
Data Management
Retrospective Studies
business.industry
Incidence
Anastomosis, Surgical
Infant, Newborn
Retrospective cohort study
General Medicine
Odds ratio
medicine.disease
Surgery
Atresia
Pediatrics, Perinatology and Child Health
Female
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 14379813 and 01790358
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Pediatric Surgery International
- Accession number :
- edsair.doi.dedup.....bcbe01be271e2b46b4acb23c10b28acd