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Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
- Source :
- AIDS research and human retroviruses. 35(1)
- Publication Year :
- 2018
-
Abstract
- Much has been learnt from the functions of host restriction factors during acute and chronic HIV-1 infection, but far less is known about their role in HIV-1-infected individuals in which viral load is stably suppressed with antiretroviral therapy (ART). In this study transcriptional expression of 42 host restriction factors was determined for memory CD4+ T cells sorted from 10 uninfected and 21 HIV-1-infected individuals, treated with suppressive ART and for which the viral reservoir was quantified. No significant associations were observed between restriction factor expression and HIV-1 reservoir size, quantified by measurement of HIV-1 Gag DNA using droplet digital polymerase chain reaction, and by measurement of replication-competent inducible virus using quantitative viral outgrowth assays. Expression of eight of the restriction factors differed significantly, and with a false discovery rate of
- Subjects :
- 0301 basic medicine
CD4-Positive T-Lymphocytes
Virus Cultivation
Immunology
Gene Expression
HIV Infections
Biology
Virus
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
T-Lymphocyte Subsets
Virology
Gene expression
medicine
Humans
Immunologic Factors
030212 general & internal medicine
APOBEC3G
Gene Expression Profiling
ISG15
Gene expression profiling
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Anti-Retroviral Agents
HIV-1
Viral load
Memory T cell
Subjects
Details
- ISSN :
- 19318405
- Volume :
- 35
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- AIDS research and human retroviruses
- Accession number :
- edsair.doi.dedup.....bcbeb93d388da15d9b04d2e29d64656e