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The effect of doubling the statin dose on pro-inflammatory cytokine in patients with triple-vessel coronary artery disease
- Source :
- Korean Circulation Journal
- Publication Year :
- 2011
-
Abstract
- Background and Objectives Statin prevents atherosclerotic progression and helps to stabilize the plaque. According to a recent study, statin reduces inflammation in blood vessels. However, it has not been demonstrated to have any anti-inflammation reaction in patients who have been diagnosed as having a triple-vessel coronary artery disease (CAD). Subjects and Methods This study included a total of thirty (30) patients who had been diagnosed by coronary angiogram as having a triple-vessel CAD. Patients who already had been taking statin were given doubled dosage. An interview, physical examination and blood test were performed at the beginning of this study and three months later. Results After doubling the dose of statin, there was no statistically significant decrease in total cholesterol, low density lipoprotein-cholesterol, (increase in) high density lipoprotein-cholesterol and triglyceride in the blood test. C-reactive protein (CRP), an acute phase reactant, significantly decreased from 0.34 mg/dL at the beginning of the study to 0.12 mg/dL at the end of study (p
- Subjects :
- Pathology
medicine.medical_specialty
Statin
medicine.drug_class
medicine.medical_treatment
Inflammation
C-reactive protein
Coronary artery disease
Internal medicine
Internal Medicine
Medicine
In patient
cardiovascular diseases
Interleukin 6
biology
business.industry
Interleukin-6
medicine.disease
Cytokine
Triple vessel coronary artery disease
Cardiology
biology.protein
Original Article
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 17385555
- Volume :
- 42
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Korean circulation journal
- Accession number :
- edsair.doi.dedup.....bcc4e929d2c30e58e3d85e9ef21f6b42