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Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host–virus coevolution
- Source :
- Virology. :60-70
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Aureococcus anophagefferens causes economically and ecologically destructive “brown tides” in the United States, China and South Africa. Here we report the 370,920bp genomic sequence of AaV, a virus capable of infecting and lysing A. anophagefferens. AaV is a member of the nucleocytoplasmic large DNA virus (NCLDV) group, harboring 377 putative coding sequences and 8 tRNAs. Despite being an algal virus, AaV shows no phylogenetic affinity to the Phycodnaviridae family, to which most algae-infecting viruses belong. Core gene phylogenies, shared gene content and genome-wide similarities suggest AaV is the smallest member of the emerging clade “Megaviridae”. The genomic architecture of AaV demonstrates that the ancestral virus had an even smaller genome, which expanded through gene duplication and assimilation of genes from diverse sources including the host itself – some of which probably modulate important host processes. AaV also harbors a number of genes exclusive to phycodnaviruses – reinforcing the hypothesis that Phycodna- and Mimiviridae share a common ancestor.
- Subjects :
- viruses
Molecular Sequence Data
Giant virus
AaV
Genome, Viral
Genome
Evolution, Molecular
Algal virus
03 medical and health sciences
Genome Size
Gene Duplication
Virology
NCLDVs
Phycodnaviridae
Megaviridae
Mimiviridae
Giant Virus
Viral evolution
Gene
Phylogeny
Brown tides
030304 developmental biology
Genetics
0303 health sciences
biology
030306 microbiology
Molecular Sequence Annotation
DNA virus
Genomics
Sequence Analysis, DNA
biology.organism_classification
DNA, Viral
Stramenopiles
Subjects
Details
- ISSN :
- 00426822
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....bcd433d2c05dadb141e7ffac9bb6293f