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Membrane-receptor initiated proliferative effects of dienogest in human breast cancer cells
- Source :
- Gynecological Endocrinology. 29:160-162
- Publication Year :
- 2012
- Publisher :
- Informa UK Limited, 2012.
-
Abstract
- Dienogest (DNG) is already used in hormone therapy, since recently being also the progestogenic component of the first estradiol based contraceptive pill. Data on breast cancer risk are currently not available. Progesterone receptor membrane component 1 (PGRMC1) is highly expressed in tissues of breast cancer patients and has already been proposed as a predictor for breast cancer risk.MCF-7 cells overexpressing PGRMC1 were stimulated with DNG, medroxyprogesterone acetate (MPA), norethisterone (NET) and progesterone (P) as well as sequentially and continuously combined with estradiol (E2).DNG and MPA alone elicited a significant proliferation at 10⁻⁶ and 10⁻⁵ M. NET increased cell proliferation at all concentrations tested whereas P showed no effect. E2 alone elicited a significant increase at 10⁻¹⁰ M, no effect was seen at 10⁻¹² M. Addition of the progestins (10⁻⁶ M) to E2 at 10⁻¹⁰ M had, compared to E2 only, no additional proliferating effect. However, at the low E2 concentration, DNG, MPA and NET significantly increased the E2-stimulated cell proliferation.DNG increased proliferation alone and in combination with low E2 concentrations. Thus a progestogen-derived breast cancer risk in the presence of low E2 concentrations cannot be excluded at least in women overexpressing PGRMC1.
- Subjects :
- medicine.medical_specialty
Neoplasms, Hormone-Dependent
Norethisterone
Endocrinology, Diabetes and Metabolism
Breast Neoplasms
Medroxyprogesterone Acetate
Biology
chemistry.chemical_compound
Endocrinology
Breast cancer
Internal medicine
Progesterone receptor
Contraceptive Agents, Female
medicine
Humans
Nandrolone
Medroxyprogesterone acetate
Drug Interactions
Receptor
PGRMC1
Progesterone
Cell Proliferation
Estradiol
Osmolar Concentration
Membrane Proteins
Obstetrics and Gynecology
Estrogens
medicine.disease
Recombinant Proteins
Clone Cells
Neoplasm Proteins
Dienogest
chemistry
Cancer cell
MCF-7 Cells
Female
Norethindrone
Progestins
Receptors, Progesterone
medicine.drug
Subjects
Details
- ISSN :
- 14730766 and 09513590
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Gynecological Endocrinology
- Accession number :
- edsair.doi.dedup.....bce086654e1999db52c04511f35c11b2