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Supplementary Figures 1-10, Supplementary Materials and Methods, Supplementary References from Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer

Authors :
James N. Arnold
James F. Spicer
Sandra S. Diebold
Shahram Kordasti
Joy M. Burchell
Stephen F. Madden
Cheryl E. Gillett
Anita Grigoriadis
Andrew Tutt
Francesco Dazzi
Mieke Van Hemelrijck
Sharanpreet Lall
Paris Kosti
Mary Okesola
Jonathan Caron
James W. Opzoomer
Tamara Muliaditan
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Figure S1â",HO-1 expression in MMTV-PyMT tumors; Supplementary Figure S2â",Effects of SnMP and chemotherapy combination therapy; Supplementary Figure S3â",HO-1+ TAMs in murine models of breast cancer; Supplementary Figure S4â",Genetic inactivation and therapeutic inhibition of myeloid HO-1 in the MMTV-PyMT model; Supplementary Figure S5â",HO-1 in human cancer; Supplementary Figure S6â",tSNE clustering identifies stromal and epithelial cell types from breast cancer patient single-cell RNA sequencing data; Supplementary Figure 7â", Single cell RNA-Seq gene expression for checkpoint molecules grouped by inferred cell type; Supplementary Figure S8â",HO-1 protein in myeloid cells in human cancer; Supplementary Figure S9â", Comparative efficacies of therapeutically targeting HO-1 and PD-1 alongside paclitaxel treatment in 4T1 tumors; Supplementary Figure S10â",Improving checkpoint blockade therapy using SnMP.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....bcf33db615b3f2d26a83fbb1327436e9
Full Text :
https://doi.org/10.1158/1078-0432.22464555.v1