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Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor
- Source :
- Cell Reports, Cell Reports, Elsevier Inc, 2016, 17 (6), pp.1473-1481. ⟨10.1016/j.celrep.2016.10.016⟩, Cell Reports, 2016, 17 (6), pp.1473-1481. ⟨10.1016/j.celrep.2016.10.016⟩, Cell Reports, Vol 17, Iss 6, Pp 1473-1481 (2016)
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- SummaryDuring spinal cord development, astrocyte precursors arise from neuroepithelial progenitors, delaminate from the ventricular zone, and migrate toward their final locations where they differentiate. Although the mechanisms underlying their early specification and late differentiation are being deciphered, less is known about the temporal control of their migration. Here, we show that the epithelial-mesenchymal transition regulator Zeb1 is expressed in glial precursors and report that loss of Zeb1 function specifically delays the onset of astrocyte precursor delamination from the ventricular zone, correlating with transient deregulation of the adhesion protein Cadherin-1. Consequently, astrocyte precursor invasion into the Zeb1−/− mutant white matter is delayed, and induction of their differentiation is postponed. These findings illustrate how fine regulation of adhesive properties influences the onset of neural precursor migration and further support the notion that duration of exposure of migrating astrocyte precursors to environmental cues and/or their correct positioning influence the timing of their differentiation.
- Subjects :
- 0301 basic medicine
Aging
cell migration
[SDV]Life Sciences [q-bio]
Regulator
Biology
General Biochemistry, Genetics and Molecular Biology
White matter
Mice
03 medical and health sciences
astrocyte
Cell Movement
medicine
Animals
Zeb2
Progenitor cell
lcsh:QH301-705.5
development
ComputingMilieux_MISCELLANEOUS
Body Patterning
Zeb1
GFAP
Stem Cells
Gene Expression Regulation, Developmental
Zinc Finger E-box-Binding Homeobox 1
spinal cord
Cell Differentiation
Embryo, Mammalian
Spinal cord
Cell biology
Neuroepithelial cell
[SDV] Life Sciences [q-bio]
Cadherin-1
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
Astrocytes
Mutation
Immunology
Ventricular zone
oligodendrocyte
Astrocyte
Sox9
Subjects
Details
- Language :
- English
- ISSN :
- 22111247
- Database :
- OpenAIRE
- Journal :
- Cell Reports, Cell Reports, Elsevier Inc, 2016, 17 (6), pp.1473-1481. ⟨10.1016/j.celrep.2016.10.016⟩, Cell Reports, 2016, 17 (6), pp.1473-1481. ⟨10.1016/j.celrep.2016.10.016⟩, Cell Reports, Vol 17, Iss 6, Pp 1473-1481 (2016)
- Accession number :
- edsair.doi.dedup.....bcf79b13a0004aead65b5e98f0887774