Back to Search
Start Over
HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype
- Source :
- Oncogene. 37:3575-3588
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- HOXB7 is a homeodomain (HOX) transcription factor involved in regional body patterning of invertebrates and vertebrates. We previously identified HOXB7 within a ten-gene prognostic signature for lung adenocarcinoma, where increased expression of HOXB7 was associated with poor prognosis. This raises the question of how HOXB7 overexpression can influence the metastatic behavior of lung adenocarcinoma. Here, we analyzed publicly available microarray and RNA-seq lung cancer expression datasets and found that HOXB7-overexpressing tumors are enriched in gene signatures characterizing adult and embryonic stem cells (SC), and induced pluripotent stem cells (iPSC). Experimentally, we found that HOXB7 upregulates several canonical SC/iPSC markers and sustains the expansion of a subpopulation of cells with SC characteristics, through modulation of LIN28B, an emerging cancer gene and pluripotency factor, which we discovered to be a direct target of HOXB7. We validated this new circuit by showing that HOXB7 enhances reprogramming to iPSC with comparable efficiency to LIN28B or its target c-MYC, which is a canonical reprogramming factor.
- Subjects :
- 0301 basic medicine
Cancer Research
Lung Neoplasms
Induced Pluripotent Stem Cells
Adenocarcinoma of Lung
Biology
Proto-Oncogene Proteins c-myc
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
Genetics
medicine
Humans
RNA, Small Interfering
Lung cancer
Induced pluripotent stem cell
Molecular Biology
Embryonic Stem Cells
Cell Proliferation
Homeodomain Proteins
Regulation of gene expression
Gene Expression Profiling
RNA-Binding Proteins
Cancer
medicine.disease
Embryonic stem cell
Gene Expression Regulation, Neoplastic
Gene expression profiling
HEK293 Cells
030104 developmental biology
030220 oncology & carcinogenesis
Neoplastic Stem Cells
Cancer research
Adenocarcinoma
RNA Interference
Reprogramming
Subjects
Details
- ISSN :
- 14765594 and 09509232
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Oncogene
- Accession number :
- edsair.doi.dedup.....bd125aa0aaffc7b14c1f66219a5af693