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An Aspiration Material Preparation System: Application of a New Liquid-Based Cytology Technique for Fine-Needle Aspiration of the Breast
- Source :
- Acta Cytologica. 55:92-99
- Publication Year :
- 2010
- Publisher :
- S. Karger AG, 2010.
-
Abstract
- Objective: To evaluate the usefulness of our original liquid-based cell preparation system AMAPS (aspiration material preparation system) and to compare it with the AutoSmear system in breast aspiration cytology. Study Design: A total of 487 specimens of fine-needle aspiration cytology of the breast were retrieved, of which 250 were processed with AMAPS and 237 with the AutoSmear method (before the introduction of AMAPS). A final histological diagnosis was obtained by an excisional biopsy or a surgical resection in 148 cases. Results: Cell recovery rates were significantly improved with AMAPS (96.8 and 99.1% in Papanicolaou and Diff-Quik, respectively) compared with the AutoSmear method (40.9 and 42.3%, respectively; p < 0.01). Within-run and day-to-day reproducibility of cell recovery was satisfactory, with coefficients of variations of 6.8 and 8.7%, respectively. Following the introduction of AMAPS in breast cytology, the unsatisfactory rate decreased significantly (from 16.0 to 8.8%; p < 0.01), while the diagnostic sensitivity for malignancy did not change (97.8 to 98.1%). Moreover, the diagnostic specificity for benign lesions increased from 75 to 93.8%, thus decreasing the excision rate of fibrocystic disease. Conclusion: AMAPS may serve as an alternative to the conventional technique or commercially available liquid-based cytology systems.
- Subjects :
- Quality Control
medicine.medical_specialty
Histology
Biopsy, Fine-Needle
Cytological Techniques
Papanicolaou stain
Breast Neoplasms
Sensitivity and Specificity
Pathology and Forensic Medicine
Histological diagnosis
Cytology
Biopsy
medicine
Humans
Breast
Retrospective Studies
Conventional technique
medicine.diagnostic_test
business.industry
Reproducibility of Results
General Medicine
Surgery
Aspiration cytology
Fine-needle aspiration
Liquid-based cytology
Female
Radiology
business
Subjects
Details
- ISSN :
- 19382650 and 00015547
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Acta Cytologica
- Accession number :
- edsair.doi.dedup.....bd370fe35acd91a234021ee3728e47c1