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The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study
- Source :
- AIDS. 22:47-56
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- Aim This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine. Methods EuroSIDA has collected information on pancreatitis since Summer 2001. All identified cases have been verified by the coordinating centre. Individuals were followed from June 2001 or the date of entry into EuroSIDA (whichever occurred later) until a diagnosis of pancreatitis or the last study visit. Factors associated with pancreatitis were investigated using Poisson regression. Cumulative lengths of exposure to didanosine without stavudine, stavudine without didanosine, stavudine with didanosine, and other ART were time-updated variables. Treatment variables were fitted with a 6-month time lag. Results There were 43 (nine presumptive) pancreatic events in 9678 individuals during 33 742 person-years (incidence 1.27/1000 person-years). The incidence among those with no, 2 or less and over 2 years' exposure to ART including stavudine and didanosine was 1.24, 1.73 and 0.78/1000 person-years, respectively. In multivariable analysis, higher baseline CD4 cell counts were associated with a decreased risk of pancreatitis. There was no evidence of an association of pancreatitis with cumulative exposure to didanosine and stavudine, didanosine without stavudine, stavudine without didanosine, or other ART. Conclusion We observed a low overall rate of pancreatitis in the years 2001-2006, and did not find an association of an increased incidence of pancreatitis with cumulative exposure to antiretroviral agents generally, and to didanosine and stavudine in particular.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
medicine.medical_specialty
Pancreatic disease
Immunology
Argentina
Cumulative Exposure
HIV Infections
Pharmacotherapy
Risk Factors
Lymphopenia
Internal medicine
medicine
Humans
Immunology and Allergy
Israel
Didanosine
Reverse-transcriptase inhibitor
business.industry
Incidence
Incidence (epidemiology)
Stavudine
HIV
Middle Aged
medicine.disease
Europe
Infectious Diseases
Anti-Retroviral Agents
Pancreatitis
Case-Control Studies
Reverse Transcriptase Inhibitors
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....bd877165972dd88f52481198822d4407
- Full Text :
- https://doi.org/10.1097/qad.0b013e3282f03094