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Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress
- Source :
- Seminars in Cancer Biology. 83:452-471
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Epigenetic changes associated with histone modifications play an important role in the emergence and maintenance of the phenotype of various cancer types. In contrast to direct mutations in the main DNA sequence, these changes are reversible, which makes the development of inhibitors of enzymes of post-translational histone modifications one of the most promising strategies for the creation of anticancer drugs. To date, a wide variety of histone modifications have been found that play an important role in the regulation of chromatin state, gene expression, and other nuclear events. This review examines the main features of the most common and studied epigenetic histone modifications with a proven role in the pathogenesis of a wide range of malignant neoplasms: acetylation / deacetylation and methylation / demethylation of histone proteins, as well as the role of enzymes of the HAT / HDAC and HMT / HDMT families in the development of oncological pathologies. The data on the relationship between histone modifications and certain types of cancer are presented and discussed. Special attention is devoted to the consideration of various strategies for the development of epigenetic inhibitors. The main directions of the development of inhibitors of histone modifications are analyzed and effective strategies for their creation are identified and discussed. The most promising strategy is the use of multitarget drugs, which will affect multiple molecular targets of cancer. A critical analysis of the current status of approved epigenetic anticancer drugs has also been performed.
- Subjects :
- 0301 basic medicine
Cancer Research
Cancer
Antineoplastic Agents
Computational biology
Histone acetyltransferase
DNA Methylation
Biology
medicine.disease
Epigenesis, Genetic
Chromatin
Histone Code
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Histone
Acetylation
Neoplasms
030220 oncology & carcinogenesis
Histone methyltransferase
medicine
biology.protein
Humans
Epigenetics
Histone deacetylase
Subjects
Details
- ISSN :
- 1044579X
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Seminars in Cancer Biology
- Accession number :
- edsair.doi.dedup.....bdaaf7d7685a3d419a0290f68df1684d
- Full Text :
- https://doi.org/10.1016/j.semcancer.2020.07.015