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Genetic architecture of acne vulgaris
- Source :
- Journal of the European Academy of Dermatology and Venereology. 31:1978-1990
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation. Here, we review our current understanding of the genetic architecture of this intriguing disease. We analysed genomewide association studies (GWAS) and candidate genes studies for acne vulgaris. Moreover, we included GWAS studies for the associated disease polycystic ovary syndrome (PCOS). Overall, the available data revealed sixteen genetic loci flagged by single nucleotide polymorphisms (SNPs), none of which has been confirmed yet by independent studies. Moreover, a GWAS for PCOS identified 21 susceptible loci. The genetic architecture is complex which has been revealed by GWAS. Further and larger studies in different populations are required to confirm or disprove results from candidate gene studies as well to identify signals that may overlap between different populations. Finally, studies on rare genetic variants in acne and associated diseases like PCOS may deepen our understanding of its pathogenesis.
- Subjects :
- Male
0301 basic medicine
Candidate gene
endocrine system diseases
Single-nucleotide polymorphism
Genome-wide association study
Dermatology
Disease
Bioinformatics
030207 dermatology & venereal diseases
03 medical and health sciences
Propionibacterium acnes
0302 clinical medicine
Acne Vulgaris
medicine
Humans
Acne
Genetics
biology
biology.organism_classification
medicine.disease
Polycystic ovary
Genetic architecture
030104 developmental biology
Infectious Diseases
Female
Genome-Wide Association Study
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 09269959
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of the European Academy of Dermatology and Venereology
- Accession number :
- edsair.doi.dedup.....bdbfad492471cca96acf6da46a94d4b0