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Noninvasive imaging evaluation of tumor immune microenvironment to predict outcomes in gastric cancer
- Source :
- Annals of Oncology. 31:760-768
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background The tumor immune microenvironment can provide prognostic and predictive information. A previously validated ImmunoScore of Gastric Cancer (ISGC) evaluates both lymphoid and myeloid cells in the tumor core and invasive margin with immunohistochemical staining of surgical specimens. We aimed to develop a noninvasive radiomics-based predictor of ISGC. Patients and methods In this retrospective study including four independent cohorts of 1778 patients, we extracted 584 quantitative features from the intratumoral and peritumoral regions on contrast-enhanced computed tomography images. A radiomic signature [radiomics ImmunoScore (RIS)] was constructed to predict ISGC using regularized logistic regression. We further evaluated its association with prognosis and chemotherapy response. Results A 13-feature radiomic signature for ISGC was developed and validated in three independent cohorts (area under the curve = 0.786, 0.745, and 0.766). The RIS signature was significantly associated with both disease-free and overall survival in the training and all validation cohorts [hazard ratio (HR) range: 0.296–0.487, all P Conclusion The RIS is a reliable tool for evaluation of immunoscore and retains the prognostic significance in gastric cancer. Future prospective studies are required to confirm its potential to predict treatment response and select patients who will benefit from chemotherapy.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
medicine.medical_treatment
Immune microenvironment
Logistic regression
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
Internal medicine
Tumor Microenvironment
medicine
Humans
Prospective Studies
Prospective cohort study
Retrospective Studies
Chemotherapy
business.industry
Hazard ratio
Cancer
Retrospective cohort study
Hematology
Prognosis
medicine.disease
030104 developmental biology
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
Immunohistochemistry
business
Subjects
Details
- ISSN :
- 09237534
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi.dedup.....bdecc22a4e0f9ebb4af1e756878ddebb