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A systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran
- Source :
- Ecotoxicology and Environmental Safety, Vol 212, Iss, Pp 111986-(2021)
- Publication Year :
- 2020
-
Abstract
- Population exposure to environmental contaminants can be precisely observed through human biomonitoring studies. The present study aimed to systematically review all the biomonitoring studies conducted in Iran on some selected carcinogen environmental pollutants. In this systematic review study, 11 carcinogen agents were selected including arsenic, cadmium, chromium, nickel, lindane, benzene, trichloroethylene (TCE), pentachlorophenol (PCP), radon-222, radium-224, − 226, − 228, and tobacco smoke. The Web of Science, PubMed, and Scopus databases were searched for peer-reviewed articles published in English. After several screening steps, data were extracted from the studies. Meta-analyses (a random-effect model using the DerSimonian-Laired method) were performed only for the biomarkers with more than three eligible articles, including cadmium in blood and breast milk, and arsenic in breast milk. Methodological quality of the studies was assessed using the Newcastle-Ottawa Quality Assessment Scale adapted for cross-sectional studies. Of the 610 articles found in the database search, 30 studies were eligible for qualitative review, and 13 were included in the meta-analysis (cadmium in blood (n = 3), cadmium in breast milk (n = 6), and arsenic in breast milk (n = 4)). The overall pooled average concentrations (95% CI) of cadmium in blood, cadmium in breast milk, and arsenic in breast milk were 0.11 (95% CI: 0.08, 0.14), 5.38 (95% CI: 3.60, 6.96), and 1.42 (95% CI: 1.02, 1.81) µg/L, respectively. These values were compared with the biomarker concentrations in other countries and health-based guideline values. This study showed that there is a need for comprehensive action plans to reduce the exposure of general population to these environmental contaminants.
- Subjects :
- Chromium
Health, Toxicology and Mutagenesis
Population
0211 other engineering and technologies
chemistry.chemical_element
02 engineering and technology
010501 environmental sciences
Breast milk
Iran
01 natural sciences
Tobacco smoke
Arsenic
chemistry.chemical_compound
Nickel
Environmental health
Biomonitoring
Medicine
Humans
GE1-350
education
0105 earth and related environmental sciences
021110 strategic, defence & security studies
Cadmium
education.field_of_study
Milk, Human
business.industry
Smoking
Public Health, Environmental and Occupational Health
General population
Biomarker
General Medicine
Environmental Exposure
Pollution
Human biomonitoring
Environmental sciences
Cross-Sectional Studies
Heavy metals
TD172-193.5
chemistry
Meta-analysis
Environmental Pollutants
Female
business
Lindane
Environmental Pollution
Biological Monitoring
Subjects
Details
- ISSN :
- 10902414
- Volume :
- 212
- Database :
- OpenAIRE
- Journal :
- Ecotoxicology and environmental safety
- Accession number :
- edsair.doi.dedup.....be0f6fd6079f99577b090da9f649228c