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Diagnostic value of anti-F-actin antibodies in a French multicenter study
- Source :
- Annals of the New York Academy of Sciences, Annals of the New York Academy of Sciences, 2005, 1050, pp.266-273
- Publication Year :
- 2005
- Publisher :
- HAL CCSD, 2005.
-
Abstract
- According to international criteria, autoimmune hepatitis (AIH) type 1 is characterized by the presence of antinuclear or anti-smooth muscle antibodies (SMA) with F-actin specificity. SMA have been found in 85% of AIH patients, but are not specific to this disease, and anti-F-actin specificity is not always verified when SMA are detected. The objective of this study was to determine the diagnostic value of anti-F-actin antibodies in a large population. A multicenter study involving 12 clinical centers was performed. Patients were selected on the basis of the presence of F-actin SMA detected by indirect immunofluorescence (IIF) on rat liver-kidney-stomach sections and was confirmed by IIF on Hep2 cells treated with colchicine, or F-actin dot-blot. The clinical status of patients was determined from their medical records. One hundred sixty-eight patients were included: 76% women, 24% men; mean age of 45 years (range, 2-88 years), with a bimodal age distribution. Sixty percent had AIH type 1, and 40% had another disease. In the group of women younger than 25 years, 90% had AIH type 1. Other pathologies associated with antiactin were other liver diseases (19%), including viral hepatitis C (7%), and non-liver diseases (21%), including connective tissue diseases (12%). Antibody titers were higher in AIH than in other diseases. Antiactin antibodies are of major diagnostic value in AIH, especially in young women; they may be found in other disease settings, but mostly at low levels.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Adolescent
Autoimmune hepatitis
Disease
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
Age Distribution
History and Philosophy of Science
Internal medicine
Cell Line, Tumor
medicine
Animals
Humans
Multicenter Studies as Topic
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Child
Connective Tissue Diseases
Fluorescent Antibody Technique, Indirect
Aged
Retrospective Studies
Hepatitis
Aged, 80 and over
Chi-Square Distribution
biology
business.industry
General Neuroscience
Antibody titer
IIf
Muscle, Smooth
Middle Aged
medicine.disease
SMA
Hepatitis C
Actins
Rats
Hepatitis, Autoimmune
Antibodies, Antinuclear
Child, Preschool
biology.protein
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
France
Antibody
business
Viral hepatitis
Colchicine
Subjects
Details
- Language :
- English
- ISSN :
- 00778923 and 17496632
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences, Annals of the New York Academy of Sciences, 2005, 1050, pp.266-273
- Accession number :
- edsair.doi.dedup.....be2dc580923eed3dc80277840a4fd541