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The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
The Nutraceutical Antihypertensive Action of C-Phycocyanin in Chronic Kidney Disease Is Related to the Prevention of Endothelial Dysfunction
- Source :
- Nutrients; Volume 14; Issue 7; Pages: 1464
- Publication Year :
- 2022
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2022.
-
Abstract
- C-phycocyanin (CPC) is an antihypertensive that is not still wholly pharmacologically described. The aim of this study was to evaluate whether CPC counteracts endothelial dysfunction as an antihypertensive mechanism in rats with 5/6 nephrectomy (NFx) as a chronic kidney disease (CKD) model. Twenty-four male Wistar rats were divided into four groups: sham control, sham-treated with CPC (100 mg/Kg/d), NFx, and NFx treated with CPC. Blood pressure was measured each week, and renal function evaluated at the end of the treatment. Afterward, animals were euthanized, and their thoracic aortas were analyzed for endothelium functional test, oxidative stress, and NO production. 5/6 Nephrectomy caused hypertension increasing lipid peroxidation and ROS production, overexpression of inducible nitric oxide synthase (iNOS), reduction in the first-line antioxidant enzymes activities, and reduced-glutathione (GSH) with a down-expression of eNOS. The vasomotor response reduced endothelium-dependent vasodilation in aorta segments exposed to acetylcholine and sodium nitroprusside. However, the treatment with CPC prevented hypertension by reducing oxidative stress, NO system disturbance, and endothelial dysfunction. The CPC treatment did not prevent CKD-caused disturbance in the antioxidant enzymes activities. Therefore, CPC exhibited an antihypertensive activity while avoiding endothelial dysfunction.
- Subjects :
- Male
Nutrition and Dietetics
Nitric Oxide Synthase Type III
C-phycocyanin
chronic kidney disease
endothelial dysfunction
nephrectomy
antihypertensive
Phycocyanin
technology, industry, and agriculture
Blood Pressure
macromolecular substances
Nitric Oxide
Antioxidants
Rats
Vasodilation
Oxidative Stress
Dietary Supplements
Hypertension
Animals
1111 Nutrition and Dietetics
Endothelium, Vascular
Rats, Wistar
Renal Insufficiency, Chronic
0908 Food Sciences
Antihypertensive Agents
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients; Volume 14; Issue 7; Pages: 1464
- Accession number :
- edsair.doi.dedup.....be363ef4ccdb175ee777f1c37cb72ec8
- Full Text :
- https://doi.org/10.3390/nu14071464