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Gabapentin provides effective postoperative analgesia whether administered pre-emptively or post-incision
- Source :
- Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 52:827-831
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- We investigated the effects of pre-incision and post-incision administration of gabapentin on postoperative pain and fentanyl consumption associated with open donor nephrectomy.Sixty ASA I subjects were randomly allocated into three groups to receive gabapentin 600 mg two hours before surgery and placebo after surgical incision (pre-incision group), placebo two hours before surgery and gabapentin 600 mg after surgical incision (post-incision group), or placebo two hours before surgery and after surgical incision (placebo group). After surgery, pain was assessed using a visual analogue scale (VAS), (1-10 cm) at time points 0, 6, 12, 18, and 24 hr. Subjects received patient-controlled-analgesia (fentanyl 1.0 microg x kg(-1) subject activated dose). Total fentanyl consumption in each group was recorded.Subjects of pre-incision and post-incision groups had lower VAS scores at all time points (3.1 +/- 1.8, 2.9 +/- 1.3, 2.8 +/- 1.3, 2.5 +/- 0.9, 2.5 +/- 1.5 and 3.6 +/- 1.1, 3.0 +/- 1.2, 3.2 +/- 1.1, 2.9 +/- 1.0, 2.6 +/- 2.2) compared to placebo group (6.6 +/- 1.3, 5.0 +/- 1.0, 4.4 +/- 0.7, 4.2 +/- 0.8, 3.9 +/- 1.0). They also used less fentanyl (563.3 microg +/- 252.8 and 624.0 microg +/- 210.5 respectively) compared to placebo (924.7 microg +/- 417.5), (P0.05). No difference in total fentanyl consumption and pain scores at any time points were observed between pre- and post-incision groups.Pre-incision administration of 600 mg gabapentin has no added benefit over post-incision administration in terms of pain scores and fentanyl consumption in subjects undergoing open donor nephrectomy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Cyclohexanecarboxylic Acids
Gabapentin
Pain medicine
medicine.medical_treatment
Analgesic
Pregabalin
Administration, Oral
Nephrectomy
Fentanyl
Double-Blind Method
Anesthesiology
Humans
Medicine
Prospective Studies
Amines
gamma-Aminobutyric Acid
Pain Measurement
Analgesics
Pain, Postoperative
business.industry
Analgesia, Patient-Controlled
General Medicine
Middle Aged
Surgery
Analgesics, Opioid
Anesthesiology and Pain Medicine
Anticonvulsant
Anesthesia
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14968975 and 0832610X
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Accession number :
- edsair.doi.dedup.....be391ca563ede0817e99fa2836eb7904