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Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn
- Source :
- Vaccine. 22:4385-4389
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Previous clinical studies have demonstrated the feasibility of using edible transgenic plants to deliver protective antigens as new oral vaccines. Transgenic corn is particularly attractive for this purpose since the recombinant antigen is stable and homogeneous, and corn can be formulated in several edible forms without destroying the cloned antigen. Transgenic corn expressing 1 mg of LT-B of Escherichia coli without buffer was fed to adult volunteers in three doses, each consisting of 2.1 g of plant material. Seven (78%) of nine volunteers developed rises in both serum IgG anti-LT and numbers of specific antibody secreting cells after vaccination. Four (44%) of nine volunteers also developed stool IgA. Transgenic plants represent a new vector for oral vaccine antigens.
- Subjects :
- Adult
Immunoglobulin A
Bacterial Toxins
Flour
Administration, Oral
Enzyme-Linked Immunosorbent Assay
Genetically modified crops
Biology
Zea mays
Immunoglobulin G
law.invention
Enterotoxins
Feces
Antigen
law
Humans
Antibody-Producing Cells
Immunity, Mucosal
Genetically modified maize
General Veterinary
General Immunology and Microbiology
Escherichia coli Proteins
Immunogenicity
Public Health, Environmental and Occupational Health
food and beverages
Plants, Genetically Modified
Virology
Recombinant Proteins
Vaccination
Infectious Diseases
Antibody Formation
biology.protein
Recombinant DNA
Molecular Medicine
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....be414c03ce9c9904acf3fac6e7a7b907
- Full Text :
- https://doi.org/10.1016/j.vaccine.2004.01.073