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S100B and homocysteine in the acute alcohol withdrawal syndrome
- Source :
- European Archives of Psychiatry and Clinical Neuroscience
- Publication Year :
- 2010
- Publisher :
- Springer-Verlag, 2010.
-
Abstract
- Elevations of serum homocysteine levels are a consistent finding in alcohol addiction. Serum S100B levels are altered in different neuropsychiatric disorders but not well investigated in alcohol withdrawal syndromes. Because of the close connection of S100B to ACTH and glutamate secretion that both are involved in neurodegeneration and symptoms of alcoholism the relationship of S100B and homocysteine to acute withdrawal variables has been examined. A total of 22 male and 9 female inpatients (mean age 46.9 ± 9.7 years) with an ICD-10 diagnosis of alcohol addiction without relevant affective comorbidity were examined on admission and after 24, 48, and 120 h during withdrawal. S100B and homocysteine levels in serum were collected, and severity of withdrawal symptoms (AWS-scale), applied withdrawal medication, initial serum ethanol levels and duration of addiction were recorded. Serum S100B and homocysteine levels declined significantly (P
- Subjects :
- Male
Time Factors
Homocysteine
Statistics as Topic
Blood Pressure
S100B
chemistry.chemical_compound
0302 clinical medicine
Heart Rate
Hypnotics and Sedatives
Pharmacology (medical)
media_common
Glutamate secretion
S100 Proteins
General Medicine
Middle Aged
Substance Withdrawal Syndrome
3. Good health
Psychiatry and Mental health
Alcohol addiction
Withdrawal
Anesthesia
Acute Disease
Female
Psychology
Chlormethiazole
medicine.drug
Adult
medicine.medical_specialty
media_common.quotation_subject
Enzyme-Linked Immunosorbent Assay
S100 Calcium Binding Protein beta Subunit
03 medical and health sciences
Sex Factors
Clomethiazole
Internal medicine
Heart rate
Medicine & Public Health
Psychiatry
Neurology
Neurosciences
medicine
Humans
Nerve Growth Factors
Biological Psychiatry
Aged
Psychiatric Status Rating Scales
Analysis of Variance
Original Paper
Addiction
medicine.disease
Comorbidity
030227 psychiatry
Blood pressure
Endocrinology
chemistry
Alcohols
Age of onset
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....be530e0c4d053b6b7ec9c2100d0508f6