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Efficacy of the paramunity inducer PIND-ORF in the treatment of canine parvovirus infection
- Source :
- The Veterinary Journal. 202:340-347
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Canine parvovirus (CPV) infection is a common and severe disease particularly affecting young dogs. The paramunity inducer PIND-ORF is reported to stimulate the innate immune system and, if used as a supplementary medication, might lead to a more rapid improvement in clinical signs in dogs with CPV infection. The aim of this study was to evaluate the efficacy of PIND-ORF in dogs with CPV infection in a prospective, placebo-controlled, double-blinded trial using 38 dogs randomly assigned to two groups. Inclusion criteria were clinical signs consistent with CPV infection and a positive faecal CPV PCR. Dogs received either PIND-ORF ( n = 20) or placebo ( n = 18) and additional symptomatic treatment. Time to recovery and mortality rate were compared between the two groups. Clinical signs, complete blood counts (CBC), and serum protein and albumin concentrations were evaluated daily during hospitalisation and on day 14. Viral shedding and antibody titres were measured by faecal CPV PCR and serum neutralisation assay. There was no significant difference in time to recovery, clinical signs, blood parameters, duration of virus shedding, and antibody titres between the two groups. The only significant difference was an increase in lymphocyte counts and antibody titres observed in the PIND-ORF group only. Three dogs receiving placebo did not survive, but the mortality rate was not significantly different between groups ( P = 0.097). No significant effect of PIND-ORF on recovery and outcome could be demonstrated.
- Subjects :
- Male
Parvovirus, Canine
animal diseases
viruses
Lymphocyte
Antibodies, Viral
Placebo
Antiviral Agents
Neutralization
Parvoviridae Infections
Feces
Dogs
Adjuvants, Immunologic
Double-Blind Method
medicine
Animals
Dog Diseases
Prospective Studies
Viral shedding
Biological Products
General Veterinary
biology
Mortality rate
Canine parvovirus
biology.organism_classification
Immunity, Innate
Virus Shedding
Clinical trial
medicine.anatomical_structure
Immunology
biology.protein
Female
Animal Science and Zoology
Antibody
Subjects
Details
- ISSN :
- 10900233
- Volume :
- 202
- Database :
- OpenAIRE
- Journal :
- The Veterinary Journal
- Accession number :
- edsair.doi.dedup.....be5e5a503cd82dba809af9e7f8435892