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Sphingosine Kinases promote IL-17 expression in human T lymphocytes
- Source :
- Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-31666-1, info:cnr-pdr/source/autori:Barra G.; Lepore A.; Gagliardi M.; Somma D.; Matarazzo M.R.; Costabile F.; Pasquale G.; Mazzoni A.; Gallo C.; Nuzzo G.; Annunziato F.; Fontana A.; Leonardi A.; De Palma R./titolo:Sphingosine Kinases promote IL-17 expression in human T lymphocytes/doi:10.1038%2Fs41598-018-31666-1/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8, Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, London , Regno Unito, 2018.
-
Abstract
- Sphingosine 1-phosphate (S1P) has a role in many cellular processes. S1P is involved in cell growth and apoptosis, regulation of cell trafficking, production of cytokines and chemokines. The kinases SphK1 and SphK2 (SphKs) phosphorilate Sphingosine (Sph) to S1P and several phosphatases revert S1P to sphingosine, thus assuring a balanced pool that can be depleted by a Sphingosine lyase in hexadecenal compounds and aldehydes. There are evidences that SphK1 and 2 may per se control cellular processes. Here, we report that Sph kinases regulate IL-17 expression in human T cells. SphKs inhibition impairs the production of IL-17, while their overexpression up-regulates expression of the cytokine through acetylation of IL-17 promoter. SphKs were up-regulated also in PBMCs of patients affected by IL-17 related diseases. Thus, S1P/S1P kinases axis is a mechanism likely to promote IL-17 expression in human T cells, representing a possible therapeutic target in human inflammatory diseases.
- Subjects :
- 0301 basic medicine
Chemokine
T-Lymphocytes
medicine.medical_treatment
Phosphatase
lcsh:Medicine
Down-Regulation
Autoimmunity
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
Sphingosine
medicine
Humans
Th17
Sphingosine Kinases
Cytokines
RNA, Messenger
lcsh:Science
Cells, Cultured
Inflammation
Th17, Autoimmunity, Sphingosine Kinases, Cytokines
Multidisciplinary
biology
Kinase
lcsh:R
Interleukin-17
human T lymphocytes
Up-Regulation
Cell biology
Phosphotransferases (Alcohol Group Acceptor)
SPHK2
030104 developmental biology
Cytokine
chemistry
Sphingosine 1-phosphate
030220 oncology & carcinogenesis
biology.protein
lcsh:Q
lipids (amino acids, peptides, and proteins)
Interleukin 17
Lysophospholipids
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-31666-1, info:cnr-pdr/source/autori:Barra G.; Lepore A.; Gagliardi M.; Somma D.; Matarazzo M.R.; Costabile F.; Pasquale G.; Mazzoni A.; Gallo C.; Nuzzo G.; Annunziato F.; Fontana A.; Leonardi A.; De Palma R./titolo:Sphingosine Kinases promote IL-17 expression in human T lymphocytes/doi:10.1038%2Fs41598-018-31666-1/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8, Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
- Accession number :
- edsair.doi.dedup.....be6a749f9a786364429671245b09ee6b
- Full Text :
- https://doi.org/10.1038/s41598-018-31666-1