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Skin-blanching is associated with FEV1, allergy, age and gender in asthma families
- Source :
- Respiratory Medicine, 106(10), 1376-1382. W B SAUNDERS CO LTD
- Publication Year :
- 2012
- Publisher :
- W B SAUNDERS CO LTD, 2012.
-
Abstract
- Background: Inhaled glucocorticosteroids reduce airway inflammation in asthma patients, thereby improving lung function and reducing airway hyperresponsiveness and symptoms. The response to glucocorticosteroids can be measured with the glucocorticosteroid skin-blanching test. We investigated if asthmatics have a lower skin-blanching response to glucocorticosteroids than non-asthmatic subjects and if asthmatics with airway obstruction have lower skin-blanching response than those without obstruction. Finally, we assessed which clinical and inflammatory parameters influence the variability in skin-blanching response.Methods: We evaluated the skin-blanching response to topical budesonide in a large group of 315 well-characterized asthmatics and their relatives (asthma n = 114, healthy n = 140, other = 61)Results: The skin-blanching scores of the asthma probands and their healthy spouses were not significantly different. The skin-blanching score of patients with FEV1 Conclusions: Asthmatics do not have lower skin-blanching response to glucocorticosteroids than healthy subjects. Furthermore, lower skin-blanching response to glucocorticosteroids is associated with lower FEV1, female gender, higher age and the absence of allergy. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
- Subjects :
- Budesonide
Male
Allergy
STRESS
INHALED CORTICOSTEROIDS
DISEASE
Norepinephrine uptake
Cohort Studies
Forced Expiratory Volume
Young adult
Child
NOREPINEPHRINE UPTAKE
integumentary system
Pigmentation
Age Factors
SMOOTH-MUSCLE CELLS
Middle Aged
Glucocorticosteroids
GLUCOCORTICOID-RECEPTOR
Skin-tests
LUNG-FUNCTION
Female
SEX
medicine.drug
Cohort study
Adult
Pulmonary and Respiratory Medicine
EXHALED NITRIC-OXIDE
medicine.medical_specialty
Adolescent
Steroid-resistance
Young Adult
Sex Factors
Internal medicine
medicine
Hypersensitivity
Humans
Family
Glucocorticoids
Asthma
Skin Tests
business.industry
Airway obstruction
medicine.disease
respiratory tract diseases
Airway Obstruction
body regions
Immunology
Exhaled nitric oxide
business
STEROID SENSITIVITY
Subjects
Details
- Language :
- English
- ISSN :
- 15323064 and 09546111
- Volume :
- 106
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Respiratory Medicine
- Accession number :
- edsair.doi.dedup.....be7032c27afe1ddad96f4ccd6c145823