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A close shave: How SARS-CoV-2 induces the loss of cilia
- Source :
- Journal of Cell Biology, Journal of Cell Biology, 2022, 221 (7), ⟨10.1083/jcb.202206023⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.
Details
- Language :
- English
- ISSN :
- 00219525 and 15408140
- Database :
- OpenAIRE
- Journal :
- Journal of Cell Biology, Journal of Cell Biology, 2022, 221 (7), ⟨10.1083/jcb.202206023⟩
- Accession number :
- edsair.doi.dedup.....be74ef28f299275efbfdd0cdc6295fdd
- Full Text :
- https://doi.org/10.1083/jcb.202206023⟩