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Cytotoxic and anti-inflammatory active plicamine alkaloids from Zephyranthes grandiflora
- Source :
- Fitoterapia. 130:163-168
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Phytochemical investigation on the 95% EtOH extract of the whole plants of Zephyranthes grandiflora resulted in the isolation of six new 4a-epi-plicamine-type alkaloids, zephygranditines A-F (1–6), including three novel 11,12-seco-plicamine-type alkaloids. The structures of the isolated compounds were established based on 1D and 2D (1H 1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven malignant melanoma cell lines and inhibitory activity for nitric oxide (NO) production and Cox-1/Cox-2. As a result, alkaloids 1–3 exhibited some cytotoxic activity against all the tested tumor cell lines with IC50 values
- Subjects :
- China
medicine.drug_class
Phytochemicals
Anti-Inflammatory Agents
Nitric Oxide
01 natural sciences
Anti-inflammatory
Nitric oxide
Mice
chemistry.chemical_compound
Alkaloids
Cell Line, Tumor
Drug Discovery
medicine
Animals
Humans
Cytotoxic T cell
Cyclooxygenase Inhibitors
Zephyranthes
Pharmacology
Molecular Structure
biology
Traditional medicine
Plant Extracts
010405 organic chemistry
Chemistry
Amaryllidaceae
General Medicine
Nuclear magnetic resonance spectroscopy
biology.organism_classification
Antineoplastic Agents, Phytogenic
In vitro
0104 chemical sciences
010404 medicinal & biomolecular chemistry
RAW 264.7 Cells
Phytochemical
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....be8ac539c268b0a6d624710fda547a4f