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Homocysteine is Linked to Macular Edema in Type 2 Diabetes
- Source :
- Current Eye Research. 39:730-735
- Publication Year :
- 2014
- Publisher :
- Informa UK Limited, 2014.
-
Abstract
- To explore the relationship between plasma total homocysteine concentration and diabetic macular edema in patients with type 2 diabetes.Patients with type 2 diabetes (n = 176) were enrolled in a cross-sectional hospital-based study. Diabetic macular edema status was documented by fundus photographs. Plasma total homocysteine concentration was measured using fluorescence polarization immunoassay. Normal control plasma homocysteine was established in 115 healthy subjects. Risk factors for diabetic macular edema were obtained from fasting blood samples and interviewer questionnaire.Diabetic patients had increased plasma homocysteine compared with normal control. Plasma homocysteine levels were higher in subjects with diabetic macular edema than without ((11.4 ± 2.7) versus (8.5 ± 1.9) (μmol/l), p = 0.000). The association of homocysteine with diabetic macular edema was independent of major risk factors for diabetic macular edema (duration of diabetes, HbA1c, lipid) and determinants of higher homocysteine concentration (age, gender, serum folate and vitamin B12, renal status, and biguanide use) (OR: 1.63 (1.02-2.14), p = 0.018). Furthermore, per increase of 5.0 μmol/l plasma homocysteine was related to macular edema, after controlling for per unit increase of other factors (OR: 1.64 (1.04-2.16), p = 0.019).Plasma total homocysteine concentration is independently associated with the occurrence of macular edema in type 2 diabetes. Future prospective studies are warranted to clarify the relationship.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
genetic structures
Homocysteine
Fundus Oculi
Diabetic macular edema
Type 2 diabetes
Fundus (eye)
Gastroenterology
Macular Edema
Retina
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Nephelometry and Turbidimetry
Risk Factors
Surveys and Questionnaires
Internal medicine
Diabetes mellitus
medicine
Humans
Prospective Studies
Fluorescein Angiography
Risk factor
Macular edema
Chromatography, High Pressure Liquid
Aged
Immunoassay
business.industry
Incidence
Healthy subjects
Middle Aged
Prognosis
medicine.disease
eye diseases
Sensory Systems
Ophthalmology
Cross-Sectional Studies
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Disease Progression
Female
sense organs
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 14602202 and 02713683
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Current Eye Research
- Accession number :
- edsair.doi.dedup.....beb68fda3fa327f8bd84532272c5d2ab