Back to Search
Start Over
Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System
- Publication Year :
- 2015
- Publisher :
- Springer US, 2015.
-
Abstract
- The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of Cur-DPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of Cur-DPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.
- Subjects :
- Male
Curcumin
Chemistry, Pharmaceutical
Pharmaceutical Science
Administration, Oral
Biological Availability
Polyethylene glycol
Poloxamer
Aquatic Science
Polyethylene Glycols
Rats, Sprague-Dawley
chemistry.chemical_compound
Castor wax
Differential scanning calorimetry
X-Ray Diffraction
Drug Discovery
PEG ratio
Spectroscopy, Fourier Transform Infrared
Animals
Solubility
Ecology, Evolution, Behavior and Systematics
Chromatography
Ecology
Calorimetry, Differential Scanning
Water
General Medicine
Bioavailability
Rats
chemistry
Powders
Agronomy and Crop Science
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bec2294a325c9ec34e8b9d0cfdec7c0a