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Gallbladder responses to modified sham feeding: effects of the composition of a meal
Gallbladder responses to modified sham feeding: effects of the composition of a meal
- Source :
- Journal of Hepatology. 19:465-469
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Changes in gallbladder contraction and plasma cholecystokinin release were studied following modified sham feeding of 3 different isocaloric meals rich in either fat, protein or carbohydrates in healthy volunteers, and results were compared with those following real feeding of comparable meals. In contrast to carbohydrate-rich meals (8 +/- 19 ml/120 min), fat- (-412 +/- 46 ml/120 min) and protein-rich meals (-352 +/- 42 ml/120 min) reduced integrated gallbladder volume (P < 0.05) in response to modified sham feeding. Plasma cholecystokinin levels were not significantly influenced by modified sham feeding of fat, protein or carbohydrates. Real feeding of a carbohydrate-rich meal also failed to significantly reduce gallbladder volume and to stimulate cholecystokinin release (-45 +/- 40 ml/120 min and 51 +/- 11 pmol/120 min, respectively), while real feeding of both fat- and protein-rich meals distinctly reduced gallbladder volume (-679 +/- 76 and -564 +/- 53 ml/120 min, respectively; P < 0.05) and increased cholecystokinin release (651 +/- 72 and 504 +/- 43 pmol/120 min, respectively; P < 0.05). This study demonstrates that gallbladder contraction during the cephalic phase of meal stimulation is dependent on the fat, protein and carbohydrate percentages of a meal, and is activated by different mechanisms than the intestinal phase of a meal.
- Subjects :
- Adult
Male
medicine.medical_specialty
Biology
Peptide hormone
Reference Values
Internal medicine
Blood plasma
Dietary Carbohydrates
medicine
Humans
Aged
Cholecystokinin
Analysis of Variance
Meal
Hepatology
Gallbladder
digestive, oral, and skin physiology
Vagus Nerve
Cephalic phase
Middle Aged
Dietary Fats
Acetylcholine
Sham feeding
medicine.anatomical_structure
Endocrinology
Gastrointestinal hormone
Female
Dietary Proteins
Subjects
Details
- ISSN :
- 01688278
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....bed85d843511d8345a394a4788ae0e5e
- Full Text :
- https://doi.org/10.1016/s0168-8278(05)80559-8