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Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review
- Source :
- Fam Cancer
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Lifestyle factors related to energy balance, such as excess body weight, poor diet, and physical inactivity, are associated with risk of sporadic endometrial cancer (EC) and colorectal cancer (CRC). There are limited data on energy balance-related lifestyle factors and EC or CRC risk among individuals with Lynch syndrome, who are at extraordinarily higher risk of developing EC or CRC. We conducted a systematic review of evidence related to weight status, weight change, dietary habits, and physical activity on EC and CRC risk among individuals with Lynch syndrome. Findings are reported narratively. We searched Medline, EMBASE, CENTRAL, PubMed, and clinicaltrials.gov up to June 14(th), 2018. In total, 1,060 studies were identified and 16 were included. Three studies were related to EC and 13 to CRC. Overall, evidence suggests that weight status/weight change may not be associated with EC risk and multivitamin and folic-acid supplementation may be associated with decreased EC risk. Early-adulthood overweight/obese weight-status and adulthood weight-gain may be associated with increased CRC risk, whereas multivitamin supplementation, tea and high fruit intake, and physical activity may be associated with decreased CRC risk. Current evidence proposes that recommendations related to weight, some dietary habits, and physical activity recommended for the general public are also relevant to individuals with Lynch syndrome. More research is needed, specifically prospective cohorts and randomized controlled trials, to determine if tailored recommendations are needed among individuals with Lynch syndrome.
- Subjects :
- Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Colorectal cancer
030105 genetics & heredity
Overweight
Article
law.invention
03 medical and health sciences
Folic Acid
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Epidemiology
Genetics
medicine
Humans
Exercise
Life Style
Genetics (clinical)
business.industry
Endometrial cancer
Body Weight
Weight change
Feeding Behavior
Vitamins
medicine.disease
Colorectal Neoplasms, Hereditary Nonpolyposis
digestive system diseases
Lynch syndrome
Endometrial Neoplasms
Oncology
030220 oncology & carcinogenesis
Female
medicine.symptom
Colorectal Neoplasms
Energy Intake
Energy Metabolism
business
Multivitamin
Subjects
Details
- ISSN :
- 15737292 and 13899600
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Familial Cancer
- Accession number :
- edsair.doi.dedup.....bee0d4e39fc68bddd3a6744b108aeb4b
- Full Text :
- https://doi.org/10.1007/s10689-019-00135-7