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Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Authors :
Steffen Blum
Stefanie Aeschbacher
Pascal Meyre
Michael Kühne
Nicolas Rodondi
Jürg H. Beer
Peter Ammann
Giorgio Moschovitis
Leo H. Bonati
Manuel R. Blum
Peter Kastner
Fiona Baguley
Christian Sticherling
Stefan Osswald
David Conen
Chloé Auberson
Leo Bonati
Selinda Ceylan
Simone Doerpfeld
Ceylan Eken
Marc Girod
Peter Hämmerle
Philipp Krisai
Christine Meyer-Zürn
Andreas U. Monsch
Christian Müller
Anne Springer
Thomas Szucs
Gian Voellmin
Leon Zwimpfer
Drahomir Aujesky
Urs Fischer
Juerg Fuhrer
Laurent Roten
Simon Jung
Heinrich Mattle
Luise Adam
Carole Elodie Aubert
Martin Feller
Axel Loewe
Elisavet Moutzouri
Claudio Schneider
Tanja Flückiger
Cindy Groen
Lukas Ehrsam
Sven Hellrigl
Alexandra Nuoffer
Damiana Rakovic
Nathalie Schwab
Rylana Wenger
Christopher Beynon
Roger Dillier
Michèle Deubelbeiss
Franz Eberli
Christine Franzini
Isabel Juchli
Claudia Liedtke
Jacqueline Nadler
Thayze Obst
Jasmin Roth
Fiona Schlomowitsch
Xiaoye Schneider
Katrin Studerus
Noreen Tynan
Dominik Weishaupt
Andreas Müller
Simone Fontana
Silke Kuest
Karin Scheuch
Denise Hischier
Nicole Bonetti
Alexandra Grau
Jonas Villinger
Eva Laube
Philipp Baumgartner
Mark Filipovic
Marcel Frick
Giulia Montrasio
Stefanie Leuenberger
Franziska Rutz
Jürg-Hans Beer
Angelo Auricchio
Adriana Anesini
Cristina Camporini
Giulio Conte
Maria Luce Caputo
Francois Regoli
Tiziano Moccetti
Roman Brenner
David Altmann
Michaela Gemperle
Mathieu Firmann
Sandrine Foucras
Martine Rime
Daniel Hayoz
Benjamin Berte
Virgina Justi
Frauke Kellner-Weldon
Brigitta Mehmann
Sonja Meier
Myriam Roth
Andrea Ruckli-Kaeppeli
Ian Russi
Kai Schmidt
Mabelle Young
Melanie Zbinden
Richard Kobza
Jane Frangi-Kultalahti
Anica Pin
Luisa Vicari
Georg Ehret
Hervé Gallet
Elise Guillermet
Francois Lazeyras
Karl-Olof Lovblad
Patrick Perret
Philippe Tavel
Cheryl Teres
Dipen Shah
Nathalie Lauriers
Marie Méan
Sandrine Salzmann
Jürg Schläpfer
Andrea Grêt
Jan Novak
Sandra Vitelli
Frank-Peter Stephan
Augusto Gallino
Marcello Di Valentino
Fabienne Witassek
Matthias Schwenkglenks
Jens Würfel
Anna Altermatt
Michael Amann
Petra Huber
Esther Ruberte
Tim Sinnecker
Vanessa Zuber
Michael Coslovsky
Pascal Benkert
Gilles Dutilh
Milica Markovic
Patrick Simon
Ramun Schmid
Clinical sciences
Auberson, Chloé
Bonati, Leo
Ceylan, Selinda
Doerpfeld, Simone
Eken, Ceylan
Girod, Marc
Hämmerle, Peter
Krisai, Philipp
Meyer-Zürn, Christine
Monsch, Andreas U.
Müller, Christian
Springer, Anne
Szucs, Thomas
Voellmin, Gian
Zwimpfer, Leon
Aujesky, Drahomir
Fischer, Urs
Fuhrer, Juerg
Roten, Laurent
Jung, Simon
Mattle, Heinrich
Adam, Luise
Aubert, Carole Elodie
Feller, Martin
Loewe, Axel
Moutzouri, Elisavet
Schneider, Claudio
Flückiger, Tanja
Groen, Cindy
Ehrsam, Lukas
Hellrigl, Sven
Nuoffer, Alexandra
Rakovic, Damiana
Schwab, Nathalie
Wenger, Rylana
Beynon, Christopher
Dillier, Roger
Deubelbeiss, Michèle
Eberli, Franz
Franzini, Christine
Juchli, Isabel
Liedtke, Claudia
Nadler, Jacqueline
Obst, Thayze
Roth, Jasmin
Schlomowitsch, Fiona
Schneider, Xiaoye
Studerus, Katrin
Tynan, Noreen
Weishaupt, Dominik
Müller, Andreas
Fontana, Simone
Kuest, Silke
Scheuch, Karin
Hischier, Denise
Bonetti, Nicole
Grau, Alexandra
Villinger, Jonas
Laube, Eva
Baumgartner, Philipp
Filipovic, Mark
Frick, Marcel
Montrasio, Giulia
Leuenberger, Stefanie
Rutz, Franziska
Auricchio, Angelo
Anesini, Adriana
Camporini, Cristina
Conte, Giulio
Caputo, Maria Luce
Regoli, Francois
Moccetti, Tiziano
Brenner, Roman
Altmann, David
Gemperle, Michaela
Firmann, Mathieu
Foucras, Sandrine
Rime, Martine
Hayoz, Daniel
Berte, Benjamin
Justi, Virgina
Kellner-Weldon, Frauke
Mehmann, Brigitta
Meier, Sonja
Roth, Myriam
Ruckli-Kaeppeli, Andrea
Russi, Ian
Schmidt, Kai
Young, Mabelle
Zbinden, Melanie
Kobza, Richard
Frangi-Kultalahti, Jane
Pin, Anica
Vicari, Luisa
Ehret, Georg Benedikt
Gallet, Hervé
Guillermet, Elise
Lazeyras, François
Lövblad, Karl-Olof
Perret, Patrick
Tavel, Philippe
Teres Castillo, Cheryl
Shah, Dipen
Lauriers, Nathalie
Méan, Marie
Salzmann, Sandrine
Schläpfer, Jürg
Grêt, Andrea
Novak, Jan
Vitelli, Sandra
Stephan, Frank-Peter
Gallino, Augusto
Di Valentino, Marcello
Witassek, Fabienne
Schwenkglenks, Matthias
Würfel, Jens
Altermatt, Anna
Amann, Michael
Huber, Petra
Ruberte, Esther
Sinnecker, Tim
Zuber, Vanessa
Coslovsky, Michael
Benkert, Pascal
Dutilh, Gilles
Markovic, Milica
Simon, Patrick
Schmid, Ramun
Source :
Heart Rhythm, Vol. 18, No 4 (2021) pp. 512-519
Publication Year :
2020

Abstract

BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend

Details

ISSN :
15563871 and 15475271
Volume :
18
Issue :
4
Database :
OpenAIRE
Journal :
Heart rhythm
Accession number :
edsair.doi.dedup.....bf07f5d003723f8745fc92a0cdac9eb3