Back to Search
Start Over
Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation
Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation
- Source :
- Heart Rhythm, Vol. 18, No 4 (2021) pp. 512-519
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
Epidemiology
Heart failure
030204 cardiovascular system & hematology
ddc:616.0757
03 medical and health sciences
0302 clinical medicine
Insulin-Like Growth Factor Binding Proteins/blood
Physiology (medical)
Internal medicine
Atrial Fibrillation
Clinical endpoint
Natriuretic peptide
medicine
Heart Failure/blood
Humans
030212 general & internal medicine
cardiovascular diseases
Hospitalization/statistics & numerical data
Aged
Retrospective Studies
ddc:616
Heart Failure
Proportional hazards model
business.industry
Insulin-like growth factor-binding protein 7
Hazard ratio
Atrial fibrillation
Middle Aged
medicine.disease
Prognosis
Confidence interval
Hospitalization
Insulin-Like Growth Factor Binding Proteins
Atrial Fibrillation/blood
Cardiology
Disease Progression
Female
business
Cardiology and Cardiovascular Medicine
Biomarkers/blood
Biomarkers
Cohort study
Follow-Up Studies
Subjects
Details
- ISSN :
- 15563871 and 15475271
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Heart rhythm
- Accession number :
- edsair.doi.dedup.....bf07f5d003723f8745fc92a0cdac9eb3