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Significance of LL-37 on Immunomodulation and Disease Outcome
- Source :
- BioMed Research International, BioMed Research International, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function. It was found that LL-37 can have two distinct functions in different tissues and different microenvironments. Thus, it is necessary to investigate LL-37 immune functions from the two sides of the same coin. On the one side, LL-37 promotes inflammation and immune response and exerts its anti-infective and antitumor effects; on the other side, it has the ability to inhibit inflammation and promote carcinogenesis. This review presents a brief summary of its expression, structure, and immunomodulatory effects as well as brief discussions on the role of this small peptide as a key factor in the development and treatment of various inflammation-related diseases and cancers.
- Subjects :
- Disease outcome
medicine.medical_treatment
Antineoplastic Agents
Inflammation
Review Article
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Cathelicidin
Immunomodulation
Mice
Immune system
Anti-Infective Agents
Cathelicidins
Neoplasms
Small peptide
medicine
Animals
Humans
Psoriasis
Biological sciences
General Immunology and Microbiology
Chemotaxis
Immune regulation
General Medicine
Inflammatory Bowel Diseases
Immunology
Medicine
medicine.symptom
Carcinogenesis
Antimicrobial Cationic Peptides
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....bf0dc3ef11594afc3adc4ea5a210e986
- Full Text :
- https://doi.org/10.1155/2020/8349712