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Correlation of serum hepatitis B core-related antigen with hepatitis B virus total intrahepatic DNA and covalently closed circular-DNA viral load in HIV–hepatitis B coinfection
- Source :
- AIDS, AIDS, Lippincott, Williams & Wilkins, 2020, 34 (13), pp.1943-1949. ⟨10.1097/QAD.0000000000002659⟩, AIDS. Official journal of the international AIDS Society, AIDS. Official journal of the international AIDS Society, 2020, 34 (13), pp.1943-1949. ⟨10.1097/QAD.0000000000002659⟩
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- International audience; Objective: To assess whether quantified hepatitis B core-related antigen (qHBcrAg) is a surrogate marker of intrahepatic replication in HIV and hepatitis B virus (HBV) coinfection.Design: Cross-sectional study of 31 HIV-HBV-infected patients (total liver biopsies, n = 38) from a well defined cohort.Methods: Spearman's rank correlation coefficients were calculated between qHBcrAg and intrahepatic markers of HBV replication [total intrahepatic-DNA, covalently closed circular (ccc) DNA, cccDNA : total intrahepatic-DNA ratio].Results: At biopsy, 22 (71.0%) patients were hepatitis B 'e' antigen (HBeAg)-positive, 22 (71.0%) had detectable plasma HBV-DNA, and 17 (54.8%) were treated with tenofovir. Median levels (interquartile range) of intrahepatic markers were as follows: HBV cccDNA (n = 34), 0.26 copies/cell (0.4-2.89); total intrahepatic-DNA (n = 38), 2.38 copies/cell (0.58-207.9), and cccDNA : total intrahepatic-DNA ratio (n = 34), 0.05 (interquartile range = 0.01-0.12). There was a significantly strong correlation between qHBcrAg and cccDNA in all patients (Rho = 0.65, P < 0.001), while a moderate correlation was observed between qHBcrAg and total intrahepatic-DNA (Rho = 0.57, P < 0.001) or cccDNA : total intrahepatic-DNA ratio (Rho = -0.45, P = 0.01). Similar findings were observed for HBeAg-positive patients and those with detectable HBV-DNA, with the exception of qHBcrAg and cccDNA or cccDNA : total intrahepatic-DNA ratio. In contrast, no significant correlation between qHBcrAg and any intrahepatic marker was observed in HBeAg-negative patients or those with undetectable HBV-DNA. No significant difference was observed in median qHBcrAg levels across liver fibrosis stages (P = 0.5).Conclusion: qHBcrAg is a potential surrogate marker of cccDNA in HIV-HBV coinfected patients, yet might be less useful with undetectable serum HBV-DNA or HBeAg-negative status. Whether qHBcrAg provides further clinical utility compared with other serological markers remains debatable.
- Subjects :
- Adult
Male
0301 basic medicine
Hepatitis B virus
medicine.medical_specialty
Biopsy
[SDV]Life Sciences [q-bio]
Immunology
HIV Infections
medicine.disease_cause
Gastroenterology
03 medical and health sciences
Hepatitis B, Chronic
0302 clinical medicine
Antigen
Interquartile range
Internal medicine
medicine
Humans
Immunology and Allergy
Hepatitis B e Antigens
030212 general & internal medicine
Coinfection
business.industry
virus diseases
cccDNA
Middle Aged
Viral Load
Hepatitis B
medicine.disease
Hepatitis B Core Antigens
3. Good health
[SDV] Life Sciences [q-bio]
Cross-Sectional Studies
030104 developmental biology
Infectious Diseases
Liver
HBeAg
DNA, Viral
Female
DNA, Circular
business
Viral load
Biomarkers
Subjects
Details
- ISSN :
- 14735571 and 02699370
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....bf3928ae4eae8d0a29ec4467896c1a63